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Ocular Pulse Amplitude in Patients With Descemet Stripping Endothelial Keratoplasty

Jivrajka, Renu MD*; Schultz, Kara L. MD*; Price, Marianne O. PhD; Price, Frances W. MD; Wilensky, Jacob T. MD*; Edward, Deepak P. MD§,∥; Vajaranant, Thasarat S. MD*

doi: 10.1097/IJG.0b013e31826a96cd
Original Studies

Purpose: To study the relationship of ocular pulse amplitude (OPA) and intraocular pressure (IOP) in eyes that have undergone successful Descemet stripping endothelial keratoplasty (DSEK).

Patients and Methods: Fifty eyes of 38 patients with successful DSEK at a single tertiary referral center were followed up for at least 3 months. At the time of the study all patients were carefully examined to rule out any clinically detectable corneal edema. IOP was measured by Goldmann applanation tonometry (GAT), pneumotonometry (PT), and dynamic contour tonometry (DCT). IOP, OPA, and quality measurements were recorded. Central corneal thickness (CCT) was measured by ultrasonic pachymetry.

Results: Mean IOP was 15.9±4.9 mm Hg by GAT, 20.3±4.6 mm Hg by PT, and 19.8±4.4 mm Hg by DCT. Mean OPA was 2.53±1.24 mm Hg. OPA was correlated with GAT (r=0.357, P=0.011) and PT (r=0.316, P=0.026). The correlation of OPA and DCT approached significance (r=0.270, P=0.058). Mean CCT was 701±65 µm (range, 529 to 928 µm). OPA was not associated with CCT (r=0.238, P=0.096).

Conclusions: In eyes with DSEK, our results showed that OPA was similar to that reported in normal eyes. Comparable with results in normal eyes, OPA was not associated with CCT but was associated with increasing IOP in DSEK eyes.

*Department of Ophthalmology and Visual Sciences, University of Illinois-Chicago, Chicago, IL

Cornea Research Foundation of America

Price Vision Group, Indianapolis, IN

§Wilmer Eye Institute, Johns Hopkins University Baltimore, MD

King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia

Disclosure: Carson Gabriel Funds and Komarek-McQueen-Hyde Glaucoma Research Funds created in honor of Dr Mark Lunde. K12HD055892 (T.S.V.), supported by the National Institute of Child Health and Human Development and the Office of Research on Women's Health, Bethesda, Maryland. The authors declare no conflict of interest.

Reprints: Thasarat S. Vajaranant, MD, Department of Ophthalmology and Visual Sciences, University of Illinois-Chicago, Chicago, IL 60612 (e-mail:

Received February 14, 2012

Accepted July 3, 2012

© 2014 by Lippincott Williams & Wilkins.