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Incidence of Deepening of the Upper Eyelid Sulcus After Topical Use of Travoprost Ophthalmic Solution in Japanese

Maruyama, Katsuhiko MD, PhD*; Shirato, Shiroaki MD, PhD*,†; Tsuchisaka, Asako MD*

doi: 10.1097/IJG.0b013e31826a7e09
Original Studies

Purpose: To investigate the incidence of deepening of the upper eyelid sulcus (DUES) with topical use of travoprost in Japanese glaucoma patients.

Patients and Methods: This prospective study enrolled 32 primary open-angle glaucoma Japanese patients who had been treated topically with travoprost unilaterally for 6 months at baseline, and started treatment in both eyes. The patients were observed during outpatient visits at 2, 4, and 6 months. At every visit, the photographs of both eyes and forehead were displayed randomly and the presence of DUES was diagnosed when 3 examiners unanimously rated the case as positive. The patients were also asked if they noticed any subjective symptom of DUES. Sex, refraction, and intraocular pressure (IOP) were evaluated as potential risk factors.

Results: DUES was identified objectively in 34% (11/32) of the patients after 2 months of treatment, and in 53% (17/32) after 4 and 6 months of treatment. The incidence was significantly higher in older patients (P<0.05), but not related to sex, refraction, pretreatment and posttreatment IOP, and IOP reduction. Finally, 41% (7/17) of patients with objectively diagnosed DUES noticed the presence of DUES by themselves. No patient dropped out of the study because of DUES.

Conclusions: DUES is a common side effect of topical travoprost treatment in Japanese glaucoma patients.

*Department of Ophthalmology, Tokyo Medical University

Yotsuya Shirato Eye Clinic, Tokyo, Japan

Disclosure: The authors declare no conflict of interest.

Reprints: Katsuhiko Maruyama, MD, PhD, Department of Ophthalmology, Tokyo Medical University, 6-7-1, Nishi-shinjuku, Shinjuku, Tokyo 160-0023, Japan (e-mail:

Received January 11, 2012

Accepted June 12, 2012

© 2014 by Lippincott Williams & Wilkins.