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Late Acute Myopia Syndrome Induced by Combination of Sulfonamide Drugs

Kozner, Pavel MD, PhD*; Simonova, Katarina MD*; Brozek, Bretislav MD, PhD*; Singh, Kuldev MD, MPH

doi: 10.1097/IJG.0b013e31829539f4
Online Articles: Case Reports

We present a case of late acute myopia syndrome following discontinuation of treatment with a combination of sulphonamide drugs. To the best of our knowledge, this is the first reported case with such a presentation, and suggests that the pathophysiological basis for the acute myopia syndrome is a rapid decrease in serum carbonic anhydrase inhibitors levels which may lead to a rebound increase in the production of aqueous humor and accumulation of suprachoroidal fluid. It is further postulated that there may be a cumulative effect of sulphonamide drug use on carbonic anhydrase activity in the ciliary body epithelium of susceptible individuals.

*Department of Ophthalmology, Hospital Na Bulovce, Prague, Czech Republic

Department of Opthalmology, Byers Eye Institute, Stanford University, Palo Alto, CA

Disclosure: The authors declare no conflict of interest.

Reprints: Pavel Kozner, MD, PhD, Department of Ophthalmology, Hospital Na Bulovce, Budinova 2, Prague 180 81, Czech Republic (e-mail:

Received October 16, 2012

Accepted March 12, 2013

© 2014 by Lippincott Williams & Wilkins.