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Structure-Function Relationship Between the Octopus Perimeter Cluster Mean Sensitivity and Sector Retinal Nerve Fiber Layer Thickness Measured With the RTVue Optical Coherence Tomography and Scanning Laser Polarimetry

Naghizadeh, Farzaneh*; Garas, Anita*; Vargha, Péter; Holló, Gábor*

doi: 10.1097/IJG.0b013e318264cda2
Original Studies

Purpose: To determine structure-function relationship between each of 16 Octopus perimeter G2 program clusters and the corresponding 16 peripapillary sector retinal nerve fiber layer thickness (RNFLT) values measured with the RTVue-100 Fourier-domain optical coherence tomography (RTVue OCT) and scanning laser polarimetry with variable corneal compensation (GDx-VCC) and enhanced corneal compensation (GDx-ECC) corneal compensation.

Methods: One eye of 110 white patients (15 healthy, 20 ocular hypertensive, and 75 glaucoma eyes) were investigated. The Akaike information criterion and the F test were used to identify the best fitting model.

Results: Parabolic relationship with logarithmic cluster mean sensitivity and linear sector RNFLT values provided the best fit. For RTVue OCT, significant (P<0.0001) coefficients of determination (R2) were found for all 16 RNFLT sectors. The R2 values were highest for the temporal, superotemporal, and inferotemporal RNFLT sectors (0.4483 to 0.5186). For GDx-VCC/ECC, significant (P<0.01) parabolic relationship was seen for all but the temporal and nasal RNFLT sectors. The overall highest R2 value (0.6943) was found for a superotemporal RNFLT sector with GDx-ECC. For some RNFLT sectors, the goodness of fit differed significantly between the imaging methods. Structure-function relationship was similar for the total population and the glaucoma subgroup, whereas no relationship (P>0.05) was found for the control eyes.

Conclusions: Mean sensitivity of the Octopus visual field clusters showed significant parabolic relationship with the corresponding peripapillary RNFLT sectors. The relationship was more general with the RTVue OCT than GDx-VCC or GDx-ECC. The results show that visual field clusters of the Octopus G program can be applied for detailed structure-function research.

*Department of Ophthalmology

Cardiovascular Center, Semmelweis University, Budapest, Hungary

Disclosure: G.H. is an unpaid consultant of Carl Zeiss Meditec Inc. and Optovue Inc. The remaining authors declare no conflict of interest.

Reprints: Gábor Holló, MD, PhD, DSc, Tömö u 25-29, 1083 Budapest, Hungary (e-mail:

Received October 12, 2011

Accepted June 5, 2012

© 2014 by Lippincott Williams & Wilkins.