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Intraocular Pressure Fluctuation in Patients With Primary Open-angle Glaucoma Combined With High Myopia

Yang, Yingxin*,†; Li, Zhen†,‡; Wang, Ningli; Wu, Lie*; Zhen, Yi; Wang, Tao; Ren, Caixia§; Peng, Xiaoxia; Hao, Jie; Xia, Yanting

doi: 10.1097/IJG.0b013e31825afc9d
Original Studies

Purpose: To investigate whether patients with primary open-angle glaucoma combined with high myopia (POAG-HM) have short-term intraocular pressure (IOP) fluctuations at resting conditions over 24 hours and after dynamic exercise.

Methods: Prospective Control Clinical Study. Eighty eyes of 80 high-tension Chinese POAG patients only on prostaglandin analog locally were categorized as per their degree of myopia (myopes 6 D or more, n=30 and between −0.76 and −5.99 D, n=29) or without myopia (n=21). Twenty-four-hour IOP fluctuations at resting conditions were observed in protocol 1, and IOP fluctuations after 10-minute exercise at 20% maximum Watt (Wmax) and followed by 5 minutes of exercise at 60% Wmax were observed in protocol 2.

Results: Twenty-four-hour IOP fluctuations at resting conditions were not statistically significant among groups (P=0.58). After 10 minutes of moderate (20% Wmax) exercise, patients with POAG-HM had significant IOP decrease (3.50±2.76 mm Hg) over other subjects (analysis of covariance, age, as a covariate, was controlled, P=0.02). After 5 minutes of heavy (60% Wmax) exercise, patients with POAG-HM had significantly a greater postexercise IOP decrease (7.57±3.47 mm Hg) than other groups (P=0.00).

Conclusions: High-tension POAG patients with high myopia on only pharmacological glaucoma therapy have significantly greater IOP fluctuations after moderate and heavy exercise and do not have greater 24-hour IOP fluctuations at resting conditions.

*Guang’anmen Hospital, China Academy of Chinese Medical Sciences

Beijing Tongren Eye Center, Beijing Tongren Hospital

Department of Epidemiology and Biostatistics, School of Public Health and Family Medicine

Department of Ophthalmology, Xuan Wu Hospital, Capital Medical University, Beijing

§Department of Anatomy, Histology and Embryology, Peking University School of Basic Medical Sciences

Beijing University of Chinese Medicine, Beijing, PR China

Yingxin Yang, MD and Zhen Li, MD contributed equally to this work and should be regarded as equivalent first author.

Disclosure: Supported by the Beijing Municipal Science & Technology Commission (Grant No. Z090507017709009). The authors declare no conflict of interest.

Reprints: Ningli Wang, MD, PhD, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 2 Chongwenmennei Street, Dongcheng District, Beijing 100730, PR China (e-mail:

Received January 4, 2012

Accepted April 16, 2012

© 2014 by Lippincott Williams & Wilkins.