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Impaired Saccadic Eye Movement in Primary Open-angle Glaucoma

Lamirel, Cédric*,†,‡; Milea, Dan§,∥; Cochereau, Isabelle*,†; Duong, Minh-Hanh*; Lorenceau, Jean

doi: 10.1097/IJG.0b013e31825c10dc
Original Studies
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Purpose: Our study aimed at investigating the extent to which saccadic eye movements are disrupted in patients with primary open-angle glaucoma (POAG). This approach followed upon the discovery of differences in the eye-movement behavior of POAG patients during the exploration of complex visual scenes.

Methods: The eye movements of 8 POAG patients and 4 healthy age-matched controls were recorded. Four of the patients had documented visual field scotoma, and 4 had no identifiable scotoma on visual field testing. The eye movements were monitored as the observers watched static and kinetic targets. The gain, latency, and velocity-peak latency of the saccades recorded were then analyzed.

Results: In POAG patients, with abnormal visual fields, watching a static target, the saccades were delayed and their accuracy was reduced, compared with those of normal observers. In POAG patients, with normal and abnormal visual fields, watching a kinetic target, a task involving precise motion analysis, the latency and accuracy of the saccades were impaired, compared with those of normal observers.

Conclusions: Our findings suggest that POAG alters saccade programming and execution particularly in the case of moving targets.

*Ophthalmology Department, Fondation Ophtalmologique Adolphe de Rothschild

Ophthalmology Department, Hôpital Bichat-Claude Bernard

CRICM, Cogimage, Université Pierre et Marie Curie, UMR 7225, CNRS, INSERM, Paris

§Ophthalmology Department, Angers University Hospital, Angers, France

Glostrup University Hospital, Copenhagen, Denmark

Disclosure: C.L. was supported by grants from “Fondation pour la Recherche Médicale,” “Fondation Berthe Fouassier,” and “Fondation de France”. The remaining authors declare no conflict of interest.

Reprints: Cédric Lamirel, MD, Fondation Ophtalmologique Adolphe de Rothschild, service du Pr Cochereau, 25-29 rue Manin, 75019 Paris, France (e-mail: clamirel@fo-rothschild.fr).

Received January 21, 2012

Accepted April 23, 2012

© 2014 by Lippincott Williams & Wilkins.