Our study aimed at investigating the extent to which saccadic eye movements are disrupted in patients with primary open-angle glaucoma (POAG). This approach followed upon the discovery of differences in the eye-movement behavior of POAG patients during the exploration of complex visual scenes.
The eye movements of 8 POAG patients and 4 healthy age-matched controls were recorded. Four of the patients had documented visual field scotoma, and 4 had no identifiable scotoma on visual field testing. The eye movements were monitored as the observers watched static and kinetic targets. The gain, latency, and velocity-peak latency of the saccades recorded were then analyzed.
In POAG patients, with abnormal visual fields, watching a static target, the saccades were delayed and their accuracy was reduced, compared with those of normal observers. In POAG patients, with normal and abnormal visual fields, watching a kinetic target, a task involving precise motion analysis, the latency and accuracy of the saccades were impaired, compared with those of normal observers.
Our findings suggest that POAG alters saccade programming and execution particularly in the case of moving targets.
*Ophthalmology Department, Fondation Ophtalmologique Adolphe de Rothschild
†Ophthalmology Department, Hôpital Bichat-Claude Bernard
‡CRICM, Cogimage, Université Pierre et Marie Curie, UMR 7225, CNRS, INSERM, Paris
§Ophthalmology Department, Angers University Hospital, Angers, France
∥Glostrup University Hospital, Copenhagen, Denmark
Disclosure: C.L. was supported by grants from “Fondation pour la Recherche Médicale,” “Fondation Berthe Fouassier,” and “Fondation de France”. The remaining authors declare no conflict of interest.
Reprints: Cédric Lamirel, MD, Fondation Ophtalmologique Adolphe de Rothschild, service du Pr Cochereau, 25-29 rue Manin, 75019 Paris, France (e-mail: email@example.com).
Received January 21, 2012
Accepted April 23, 2012