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Comparison of Glaucoma Diagnoses Using Stratus and Cirrus Optical Coherence Tomography in Different Glaucoma Types in a Chinese Population

Chen, Hsin-Yi MD*,†; Chang, Yue-Cune PhD; Wang, I-Jong MD, PhD*,§; Chen, Wen-Chi MD, PhD*,∥

doi: 10.1097/IJG.0b013e3182594f42
Original Studies

Purpose: To compare the glaucoma diagnostic power of Stratus and Cirrus optical coherence tomographies (OCTs) in a Taiwan Chinese population with different glaucoma types.

Patients and Methods: One eye each was chosen from 21 ocular hypertension (OH) patients, 27 glaucoma-suspect (GS) patients, 35 primary open-angle glaucoma (POAG) patients, 26 primary angle-closure glaucoma (PACG) patients, and 52 normal subjects. Early glaucoma (EG) was identified among glaucomatous eyes on the basis of the visual field severity (better than −9 dB). All participants were imaged using 2 OCT units at the same visit. The area under the receiver operator characteristic (AROC) curve was used to differentiate normal eyes from OH, GS, POAG, PACG, and EG eyes, and the sensitivity and specificity of each parameter from internal normative classifications were analyzed.

Results: For normal versus OH eyes, the best AROC value was the average thickness (Stratus, 0.693; Cirrus, 0.697). For normal versus GS eyes, the best AROC value was the average thickness (Stratus, 0.807; Cirrus, 0.776). For normal versus POAG eyes, the best AROC value was the average thickness (Stratus, 0.943; Cirrus, 0.930). For normal versus PACG eyes, the best AROC value was the 5-o’clock hour (Stratus, 0.830; Cirrus, 0.817). For normal versus EG eyes, the best AROC value was the average thickness with Stratus (0.868) and the 5-o’clock hour with Cirrus (0.876). All sensitivities in the 5 groups were fair on the basis of the internal normal classification database of both OCTs.

Conclusions: Cirrus and Stratus OCTs showed equal diagnostic power in EG, OH, GS, POAG, and PACG eyes in a Taiwan Chinese population. The utility of the current internal databases of both OCT units for the Chinese population is an interesting issue that needs to be addressed in the future.

*Graduate Institute of Clinical Medical Science, Medical College, China Medical University

Glaucoma Service, Department of Ophthalmology, China Medical University Hospital

Department of Integrated Medicine, Chinese College, China Medical University, Taichung

Department of Mathematics, Tamkang University

§Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan

Author contributions: H-Y.C.: conception and design, acquisition of data, analysis and interpretation of data, drafting of the manuscript, critical revision of the manuscript for important intellectual content, obtaining funding; Y-C.C.: statistical expertise, analysis and interpretation of data, drafting of the manuscript; I-J.W. and W-C.C.: conception and design, critical revision of the manuscript for important intellectual content.

Supported under contract no. DMR-99-092 and DMR-100-098.

Disclosure: The authors declare no conflicts of interest.

Reprints: Hsin-Yi Chen, MD, Glaucoma Service, Department of Ophthalmology, China Medical University Hospital, #2, Yuh-Der Road, Taichung City 404, Taiwan (e-mail: hsin7850@url.com.tw).

Received October 18, 2011

Accepted April 6, 2012

© 2013 by Lippincott Williams & Wilkins.