Original StudiesAbility of Fourier-domain Optical Coherence Tomography to Detect Retinal Ganglion Cell Complex Atrophy in Glaucoma PatientsSevim, Mehmet Sahin MD; Buttanri, Bulent MD; Acar, Banu Torun MD; Kahya, Alev PhD; Vural, Ece Turan MD; Acar, Suphi MDAuthor Information Department of Ophthalmology, Haydarpasa Numune Research and Education Hospital, Istanbul, Turkey Disclosure: The authors declare no conﬂict of interest. Reprints: Mehmet Sahin Sevim, MD, Kentplus sitesi, 3.Etap, D6-64 34746 Atasehir, Istanbul, Turkey (e-mail: [email protected]). Received May 26, 2011 Accepted January 9, 2012 Journal of Glaucoma: September 2013 - Volume 22 - Issue 7 - p 542-549 doi: 10.1097/IJG.0b013e31824d1f97 Buy Metrics Abstract Purpose: To evaluate the diagnostic ability of Fourier-domain optical coherence tomography (FD-OCT) measurements in both normal individuals and patients with different stages of glaucoma. Patients and Methods: A total of 113 patients diagnosed with glaucoma and classified into different stages of glaucoma according to Glaucoma Staging System 2 and 30 healthy individuals were included in this study. In all patients, parameters of both the retinal ganglion cell complex (GCC) and the peripapillary retinal nerve fiber layer were measured by FD-OCT (RTVue-100). Comparisons were made from measurements in patients with different stages of glaucoma. Results: Both GCC and retinal nerve fiber layer thickness values of patients with glaucoma were statistically significantly lower compared with those of healthy individuals. As the stage of glaucoma progressed, the mean GCC and retinal nerve fiber layer thickness values decreased. Conclusions: GCC and retinal nerve fiber layer thickness measurements performed by FD-OCT showed high diagnostic ability in detecting glaucoma. Mean thickness values can be determined for each glaucoma stage. Copyright © 2013 Wolters Kluwer Health, Inc. All rights reserved.