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A Short-term Randomized Clinical Trial of Daily Versus Alternate Day Use of Travoprost 0.004% in the Treatment of Ocular Hypertension

Khairy, Hany A. FRCSEd (Ophth), FRCSG, MD*; Said-Ahmed, Khaled FRCSG, MD*,†

doi: 10.1097/IJG.0b013e3182311de5
Original Studies

Purpose: To compare the daily versus the alternate day use of travoprost 0.004% in lowering the intraocular pressure (IOP) in patients with ocular hypertension.

Methods: Fourteen patients with ocular hypertension in both eyes have been randomly assigned to receive travoprost 0.004% once a day in 1 eye and once every other day in the other eye. The main outcome measure was change in the mean of the IOPs measured at 9:00 AM, and 4:00 PM between baseline (before treatment) and measurement of IOPs at 1, 2, 4, 8, and 12 weeks after treatment.

Results: After 3 months of treatment, daily use of travoprost 0.004% significantly reduced IOP (mean±standard error of mean) by 6.1±0.5 mmHg (P<0.001) and alternate day use by 5.9±0.3 mmHg (P< 0.001) adjusted from an overall baseline of 24.3±0.5 mm Hg. The difference in the IOP-lowering effect was not statistically significant (P<0.05).

Conclusions: Alternate day use of travoprost 0.004% was as safe and effective as its daily use in lowering the IOP in patients with ocular hypertension.

*Ophthalmology Department, Minoufiya University Hospital, Menoufiya, Egypt

Ophthalmology Department, Al-Orf Hospital, Jahra, Kuwait

Disclosure: The authors declare no conflict of interest.

Reprints: Hany A. Khairy, Ophthalmology Department, Menoufiya University Hospitals, Shebin Elkom, Menoufiya, Egypt (e-mail:

Received November 24, 2010

Accepted July 25, 2011

© 2013 Lippincott Williams & Wilkins, Inc.