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Central Corneal Thickness and Intraocular Pressure in a Nepalese Population: The Bhaktapur Glaucoma Study

Thapa, Suman S. MD*; Paudyal, Indira MD*; Khanal, Shankar PhD; Paudel, Nabin OD; Mansberger, Steven L. MD, MPH§; van Rens, Ger H.M.B. MD, PhD

doi: 10.1097/IJG.0b013e3182182c0f
Original Studies

Purpose The purpose of the study was to evaluate the characteristics of central corneal thickness and its association with age, sex, and intraocular pressure in a Nepalese population.

Patients and Methods The study design was a cross-sectional, population-based survey. Two thousand three hundred thirty patients aged 40 years and older were examined at Tilganga Institute of Ophthalmology, a tertiary referral eye centre in Kathmandu, Nepal. All patients underwent a complete ophthalmic examination that included measurements of central corneal thickness with an ultrasonic pachymeter and intraocular pressure with a Goldman type applanation tonometer.

Results The main outcome measures were central corneal thickness and intraocular pressure. Mean age of the 2330 patients examined was 51.3 years (SD±9.56). The mean central corneal thickness and mean intraocular pressure was 539.10 μm (SD±33.73) and 13.33 mm Hg (SD±2.26), respectively. Central corneal thickness showed an average decrease of 2.67 μm (95% confidence interval, 2.21-4.1) per decade increase in age. A 100 μm increase in central corneal thickness was associated with a 1.03 mm Hg (95% confidence interval, 0.79-1.26) increase in intraocular pressure after adjusting for age and sex.

Conclusions The changes in central corneal thickness values cause a significant variation in intraocular pressure in this population, suggesting that measurement of central corneal thickness will have implications in the diagnosis and management of glaucoma.

*Nepal Glaucoma Eye Clinic, Tilganga Institute of Ophthalmology

Central Department of Statistics, Tribhuvan University

Sudrishti Eye Clinic, Kathmanudu, Nepal

§Devers Eye Institute, Portland, Oregon, USA

Vrije Universiteit Amsterdam, The Netherlands

The authors declare no conflict of interest.

Reprints: Suman S. Thapa, MD, Nepal Glaucoma Eye Clinic, Tilganga Institute of Ophthalmology, PO Box 561, Kathmandu, Nepal. (e-mail:

Received August 19, 2010

Accepted February 28, 2011

© 2012 Lippincott Williams & Wilkins, Inc.