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Central Corneal Thickness in Chinese Subjects With Primary Angle Closure Glaucoma

Pang, Claudine E. MRCS(Ed)*; Lee, Kelvin Y. FRCS(Ed)*; Su, Daniel H. FRCS(Ed)*; Htoon, Hla M. PhD*; Ng, Jamie Y. MRCS(Ed); Kumar, Rajesh S. MS(Ophth)*; Aung, Tin MD, PhD*,†

doi: 10.1097/IJG.0b013e3181f3e5d9
Original Studies

Purpose To characterize central corneal thickness (CCT) in Chinese eyes with primary angle closure glaucoma (PACG).

Methods CCT was measured by ultrasound pachymetry in PACG eyes and compared with primary open-angle glaucoma (POAG) eyes. POAG eyes were further subdivided into high-tension glaucoma (HTG) and normal-tension glaucoma (NTG) for analysis. PACG eyes had glaucomatous optic neuropathy and visual field loss, an angle in which at least 180 degrees of angle in which the posterior trabecular meshwork was not visible, and raised intraocular pressure (IOP) and/or peripheral anterior synechiae. Both HTG (IOP >21 mm Hg) and NTG (IOP consistently <21 mm Hg) eyes had glaucomatous optic neuropathy with compatible visual field defects and open angles. Further comparison was made with CCT data of 1067 normal subjects previously enrolled in a population-based study.

Results We enrolled 154 patients with PACG and 300 with POAG. Mean age of PACG patients was 68.1±8.3 years compared with 71.1±12.4 years in POAG patients (P=0.002). There was no difference in mean CCT of PACG eyes (541.28±33.95 μm) and POAG eyes (539.28±34.84 μm, P=0.56) or normal eyes of control subjects (536.74±31.08 μm) (P=0.07). However, mean CCT of NTG eyes (535.23±36.10 μm) was significantly lower than that of HTG eyes (543.44±33.10 μm, P=0.04), and HTG eyes had thicker CCT than normal eyes (P=0.01).

Conclusions PACG eyes had similar CCT as those with POAG or normal eyes in Chinese subjects.

*Department of Ophthalmology, Singapore Eye Research Institute and Singapore National Eye Center

Yong Loo Lin School of Medicine, National University of Singapore, Singapore

Grants from National Medical Research Council and National Medical Research Foundation, Singapore.

Financial Support: Nil.

Disclosure: The authors declare no conflict of interest.

Reprints: Tin Aung, MD, PhD, Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore 168751 (e-mail:

Received January 5, 2010

Accepted July 18, 2010

© 2011 Lippincott Williams & Wilkins, Inc.