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Correlation Between Peripapillary Retinal Nerve Fiber Layer Thickness and Optic Nerve Head Parameters Using Spectral Domain Optical Coherence Tomography

Mansoori, Tarannum MS*; Viswanath, Kalluri MS*; Balakrishna, Nagalla PhD

doi: 10.1097/IJG.0b013e3181d12e03
Original Studies

Aim To evaluate correlation between peripapillary retinal nerve fiber layer thickness (RNFL) and optic nerve head (ONH) parameters in normal participants using Spectral domain optical coherence tomography (OCT).

Methods Sixty-five eyes of 65 healthy participants aged 13–79 years underwent ONH analysis and peripapillary RNFL thickness measurements using spectral domain OCT. The RNFL measurements were correlated with the data obtained with ONH analysis.

Results The average and quadrant RNFL thickness did not show correlation with optic disc area. A positive correlation was found between average RNFL thickness and rim area (r=0.425, P=0.000) and negative correlation between average RNFL thickness and cup area (r=−0.249, P<0.046).

Conclusions In our study, peripapillary RNFL thickness as measured by OCT did not show correlation with optic disc size. Despite a shorter distance between optic disc and circular scan margin, larger discs did not show a thicker RNFL. Interindividual variability of disc area probably minimizes the effect of various ONH size on RNFL thickness measurement.

*Department of Glaucoma, Pushpagiri Eye Institute, West Marredpally, Secunderabad

Department of Biostatistics, National Institute Of Nutrition, Hyderabad, Andhra Pradesh, India

Conflicts of interest/financial disclosure: none declared.

The authors have no commercial or proprietary interest in OCT.

Reprints: Tarannum Mansoori, MS, Department of Glaucoma, Pushpagiri Eye Institute, 241, Uma Plaza, 10-2-342, Road No 9, West Marredpally, Secunderabad-500026, Andhra Pradesh, India (e-mail:

Received July 23, 2009

Accepted December 22, 2009

© 2010 Lippincott Williams & Wilkins, Inc.