To study optic nerve head (ONH) topography parameters measured by Stratus optical coherence tomography (OCT) in normal subjects and to analyze ONH data for differences in relation to disc size, ethnicity, and age.
Three hundred sixty-seven normal subjects underwent Stratus optical coherence tomography ONH measurement using the fast optic disc scan protocol software package 3.0. Only ONH scans meeting specific qualification criteria were included for data analysis ensuring appropriate scan quality and reliability. ONH topographic parameters of qualified scans were analyzed for differences in regards to optic disc size, age, and ethnicity.
Two hundred and twelve qualified ONH scans were included for data analysis. Mean disc area was 2.27±0.41 mm2 and optic cup area, rim area, and horizontal integrated rim width increased with disc size, whereas vertical integrated rim area did not. Vertical integrated rim area, horizontal integrated rim width, and rim area decreased and cup area increased with age. Mean optic disc area was larger in African-Americans as compared with Hispanics or Whites and this difference was statistically significant.
Optic cup area, rim area, and horizontal integrated rim width correlated to disc size. Vertical integrated rim area, horizontal integrated rim width, rim area, and cup area, changed with age. African-American optic discs had larger disc area measurements as compared with Whites optic discs and this difference was statistically significant.
*Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN
†Carl Zeiss Meditec, Inc, Dublin
§Valley Eye Care Center, Pleasanton
♯Department of Ophthalmology, Doheny Eye Institute, University of Southern California, Los Angeles, CA
‡Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami and Palm Beach Gardens, FL
∥New England Eye Center, Boston, MA
¶Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA
Funding/Support: Carl Zeiss Meditec, Inc, Dublin, CA.
Financial Disclosures: None. Barbara C. Marsh (now employed by Eye Associates of New Mexico, Albuquerque, NM); Rohit Varma, and V. Michael Patella employed by Carl Zeiss Meditec, Inc, Dublin, CA; Jennifer Lipyanik previously employed by Carl Zeiss Meditec, Inc, Dublin, CA (now employed by Cutera, Brisbane, CA); Donald Budenz received lecture fees from Carl Zeiss Meditec, Inc; David Greenfield received consulting fees and grant support from Carl Zeiss Meditec, Inc; Joel Schuman received consulting and lecture fees and is an inventor of OCT from Carl Zeiss Meditec, Inc.
Reprints: Louis B. Cantor, MD, Department of Ophthalmology, Indiana University School of Medicine, 702 Rotary Circle, RM 140B, Indianapolis, IN 46202 (e-mail: firstname.lastname@example.org).
Received for publication February 19, 2009
accepted July 10, 2009
Statement about Conformity with Author Information: Reviewed and approved by the Indiana University-Purdue University Indianapolis and Clarian Institutional Review Board.