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Corneal Viscoelasticity Differences Between Diabetic and Nondiabetic Glaucomatous Patients

Castro, Dinorah Piacentini Engel MD* †; Prata, Tiago Santos MD* ‡; Lima, Verônica Castro MD* ‡; Biteli, Luis Gustavo MD*; de Moraes, Carlos Gustavo Vasconcelos MD; Paranhos, Augusto Jr MD*

doi: 10.1097/IJG.0b013e3181b4caa1
Original Study

Purpose To investigate corneal viscoelasticity in primary open-angle glaucoma patients with and without diabetes mellitus, and to correlate corneal hysteresis (CH) with central corneal thickness (CCT).

Methods In this cross-sectional study, 44 primary open-angle glaucoma patients [19 with diabetes (34 eyes) and 25 without diabetes (40 eyes)] underwent a complete ophthalmic examination. Data collected by masked investigators included CH and CCT using the Ocular Response Analyzer. The mean of 3 measurements was considered for each test. We analyzed the difference between the mean CH in both groups using a general linear model. Partial correlation coefficient between CH and CCT was also calculated.

Results Mean±SD age in diabetic and nondiabetic groups was 67.1±8.7 and 65.9±15.1, respectively (P=0.77). There was no significant difference regarding mean CCT between diabetic (531.7±31.3 μm) and nondiabetic (546.6±37.3 μm) groups (P=0.21). Patients with diabetes presented significantly higher CH values than patients without diabetes (9.1±1.9 mm Hg vs. 7.8±1.7 mm Hg, P=0.04). There was a significant and positive correlation between CH and CCT for all patients (r=0.407, P<0.001).

Conclusions Primary open-angle glaucoma patients with diabetes have significantly higher CH values than those without diabetes. CH and CCT results were positively correlated. These findings merit further investigation to assess the role of different CH values on glaucoma evaluation and susceptibility.

*Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil

New England Eye Center/Tufts Medical Center, Tufts University school of Medicine, Boston, MA

Einhorn Clinical Research Center, The New York Eye and Ear Infirmary, New York, NY

No financial interest to disclose.

Reprints: Dinorah Piacentini Engel Castro, MD, Rua Joaquim Ribeiro de Souza, 1071, CEP 13563-330, Sao Carlos, São Paulo, Brazil (e-mail:

Received for publication August 21, 2008

accepted June 20, 2009

© 2010 Lippincott Williams & Wilkins, Inc.