Original StudiesA Comparison of the Intervisit Intraocular Pressure Fluctuation After 180 and 360 Degrees of Selective Laser Trabeculoplasty (SLT) as a Primary Therapy in Primary Open Angle Glaucoma and Ocular HypertensionPrasad, Navin MD*; Murthy, Shashidhar MS, FRCS*; Dagianis, John J. MD†; Latina, Mark A. MD‡ Author Information *Massachusetts Eye and Ear Infirmary ‡Tufts University School of Medicine, Boston, MA †Nashua Eye Associates, Nashua, NH Financial Disclosures: Mark A. Latina, MD is the inventor of laser device, Selective Laser Trabeculoplasty (SLT), used in this study and he receives the inventor royalties on this device. Authors Navin Prasad, MD, Shashidhar Murthy, MD, and John J. Dagianis, MD have no proprietary or financial interest in any aspect of the study. Reprints: Mark A. Latina, MD, Tufts University School of Medicine, 20 Pond Meadow Drive, No. 203, Reading, Boston, MA 01867 (e-mail: [email protected]). Received for publication September 30, 2007; accepted March 17, 2008 This study was presented in part as a poster at the annual meeting of the Association for Research in Vision and Ophthalmology (ARVO), May 4, 2006, Fort Lauderdale, FL. Journal of Glaucoma 18(2):p 157-160, February 2009. | DOI: 10.1097/IJG.0b013e3181752c97 Buy Metrics Abstract Objective To determine and compare the effect of 180 and 360 degrees of selective laser trabeculoplasty (SLT) treatment as a primary therapy on the intervisit intraocular pressure (IOP) fluctuation in patients followed up for a period of 2 years without any further medical or surgical intervention. Methods Retrospective chart review of patients with ocular hypertension and primary open angle glaucoma who received SLT as primary therapy without any subsequent medical or surgical intervention. IOP before SLT and postlaser IOP at all the visits during the follow-up period of months 6 to 24 was determined. The standard deviation (SD) of the mean IOP was used as a surrogate for IOP fluctuation. Results Forty-one eyes were treated by SLT, 19 eyes in the 180-degree group and 22 eyes in the 360-degree group. The mean reduction in IOP at 2 years was 28% in 180-degree group and 35% in 360-degree SLT group. After the SLT, the 360-degree SLT group had a lower IOP fluctuation compared with the 180-degree SLT group over the follow-up period of months 6 to 24. The percentage of eyes with intervisit IOP fluctuation (SD) ≤2 mm Hg during the same follow-up period was significantly greater in 360-degree SLT treatment group (86%) than in the 180-degree SLT treatment group (52%), P=0.03. The odds of achieving IOP fluctuation ≤2 mm Hg were 5.7 times greater with 360 degrees than with 180-degree SLT during the follow-up period of months 6 to 24. Conclusions This study suggests that 360-degree SLT is more efficacious in achieving smaller IOP fluctuations than treatment with 180-degree SLT. © 2009 Lippincott Williams & Wilkins, Inc.