To illustrate changes in bleb vascularity after subconjunctival bevacizumab injection.
Longitudinal changes in bleb vascularity were followed over 6 months pre and postbevacizumab injection.
Bleb vascularity associated with increased scarring activity was observed 10 days postcataract surgery in an eye that had undergone trabeculectomy 3 months previously. A single subconjunctival avastin injection led to a dramatic reduction in bleb vascularity for 6 weeks. With continued steroids, a diffuse, healthy, well functioning bleb with minimal scar tissue was present at 6 months.
Subconjunctival injection of bevacizumab reduced bleb vascularity and may provide an adjunct to current antifibrosis therapy. Further studies to establish the effect of bevacizumab on postoperative scaring are warranted.
*Centre for Eye Research Australia, University of Melbourne
†Glaucoma Investigation and Research Unit, Royal Victoria Eye and Ear Hospital, East Melbourne, Australia
Reprints: Dr Jonathan G. Crowston, MD, PhD, Centre for Eye Research Australia, University of Melbourne, Locked Bag 8, East Melbourne, Vic 8002, Australia (e-mail: email@example.com).
Received for publication August 3, 2007; accepted September 20, 2007