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Vascular Changes After Intra-bleb Injection of Bevacizumab

Coote, Michael A. MBBS, FRANZCO* †; Ruddle, Jonathan B. MBBS, FRANZCO* †; Qin, Queena BMedSci*; Crowston, Jonathan G. MD, PhD* †

doi: 10.1097/IJG.0b013e31815f5345
Case Report

Purpose To illustrate changes in bleb vascularity after subconjunctival bevacizumab injection.

Methods Longitudinal changes in bleb vascularity were followed over 6 months pre and postbevacizumab injection.

Results Bleb vascularity associated with increased scarring activity was observed 10 days postcataract surgery in an eye that had undergone trabeculectomy 3 months previously. A single subconjunctival avastin injection led to a dramatic reduction in bleb vascularity for 6 weeks. With continued steroids, a diffuse, healthy, well functioning bleb with minimal scar tissue was present at 6 months.

Conclusions Subconjunctival injection of bevacizumab reduced bleb vascularity and may provide an adjunct to current antifibrosis therapy. Further studies to establish the effect of bevacizumab on postoperative scaring are warranted.

*Centre for Eye Research Australia, University of Melbourne

Glaucoma Investigation and Research Unit, Royal Victoria Eye and Ear Hospital, East Melbourne, Australia

Reprints: Dr Jonathan G. Crowston, MD, PhD, Centre for Eye Research Australia, University of Melbourne, Locked Bag 8, East Melbourne, Vic 8002, Australia (e-mail:

Received for publication August 3, 2007; accepted September 20, 2007

© 2008 Lippincott Williams & Wilkins, Inc.