To assess anxiety and depression in patients with primary open-angle glaucoma (POAG).
Multicenter prospective case-control study.
Two hundred thirty patients with POAG and 230 sex-matched and age-matched reference subjects with no chronic ocular conditions except cataracts.
Anxiety and depression were evaluated using Hospital Anxiety and Depression Scale (HADS) questionnaire, which consists of 2 subscales with ranges of 0 to 21, representing anxiety (HADS-A) and depression (HADS-D).
The prevalence of POAG patients with anxiety (a score of more than 10 on the HADS-A) or depression (a score of more than 10 on the HADS-D) was compared with that in the reference subjects. The prevalence of patients with depression was compared between the POAG patients with and without current β-blocker eye drops.
The prevalence (13.0%) of POAG patients with anxiety was significantly higher (P=0.030) than in the reference subjects (7.0%). The prevalence (10.9%) of POAG patients with depression was significantly higher (P=0.026) than in the reference subjects (5.2%). Between the POAG patients with and without β-blocker eye-drops, no significant difference (P=0.93) in the prevalence of depression was noted.
POAG was related to anxiety and depression. No significant relationship between the use of β-blocker eye-drops and depression was noted.
Departments of *Ophthalmology
§Health Sciences, Faculty of Medicine, University of Yamanashi, Yamanashi
†Cancer Information and Epidemiology Division, National Cancer Center Research Institute, Tokyo
∥Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Competing Interests: None.
Reprints: Dr Fumihiko Mabuchi, MD, PhD, Department of Ophthalmology, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898, Japan (e-mail: firstname.lastname@example.org).
Received for publication August 1, 2007; accepted November 18, 2007