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Possible Association Between Long Anterior Lens Zonules and Plateau Iris Configuration

Roberts, Daniel K. OD, MS*; Ayyagari, Radha PhD; Moroi, Sayoko E. MD, PhD

doi: 10.1097/IJG.0b013e31815c3b04
Case Report

Purpose To report plateau iris configuration (PIC) in subjects who have the long anterior zonule (LAZ) clinical trait.

Methods Two elderly African American males who exhibited LAZ and had partial appositional angle closure persisting after laser iridotomy were imaged with high-resolution ultrasonography to examine for PIC. A third elderly LAZ subject who had narrow angles without closure was also imaged for PIC. Each subject was tested for a serine 163 arginine mutation (S163R) C1q tumor necrosis factor-related protein 5 gene (C1QTNF5/CTRP5) mutation, which may be associated with the LAZ phenotype.

Results All 3 LAZ subjects also had PIC, an unlikely association due to chance alone. None carried the S163R CTRP5 mutation.

Conclusions LAZ and PIC may have association and require study because LAZ might be a useful indicator for an increased likelihood of PIC and risk of angle closure. Mutation other than CTRP5 S163R should also be considered for the LAZ trait, which could be an important phenotypic marker in genetic studies.

*Illinois Eye Institute, Illinois College of Optometry, Chicago, IL

Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI

Support: Unrestricted research grants from Alcon Labs Inc (D.K.R.); NEI EY13198 (R.A.), the Foundation Fighting Blindness (R.A.); NEI core grant to the University of Michigan, Department of Ophthalmology and Visual Sciences EY07003.

The authors have had full access to all the data in the study and took responsibility for the integrity of the data and the accuracy of the data analysis.

Reprints: Daniel K. Roberts, OD, MS, Illinois Eye Institute, Illinois College of Optometry, 3241 S. Michigan Avenue, Chicago, IL 60616 (e-mail:

Received for publication July 30, 2007; accepted September 23, 2007

© 2008 Lippincott Williams & Wilkins, Inc.