Original StudiesOcular Pulse Amplitude in Normal Tension and Primary Open Angle GlaucomaStalmans, Ingeborg MD, PhD*; Harris, Alon PhD†; Vanbellinghen, Veerle BSc*; Zeyen, Thierry MD, PhD*; Siesky, Brent PhD† Author Information *Department of Ophthalmology, University Hospitals Leuven, Leuven, Belgium †Department of Ophthalmology, Indiana University School of Medicine, IN Supported by a Medical School Grant from Merck Sharp and Dohme. Reprints: Ingeborg Stalmans, MD, PhD, Department of Ophthalmology, University Hospitals Leuven, Campus St Raphaël, Kapucijnenvoer 33, B-3000 Leuven, Belgium (e-mail: [email protected]). Received for publication May 11, 2007; accepted September 27, 2007 Journal of Glaucoma: August 2008 - Volume 17 - Issue 5 - p 403-407 doi: 10.1097/IJG.0b013e31815c5f2c Buy Metrics Abstract Purpose (1) To investigate the relationship of ocular pulse amplitude (OPA) with intraocular pressure (IOP) and corneal thickness. (2) To evaluate OPA in patients with primary open angle and normal tension glaucoma (NTG). Methods Patients with NTG (n=28), primary open angle glaucoma (POAG) (n=19), and age-matched healthy controls (n=22) underwent 2 consecutive Goldmann and dynamic contour tonometry measurements within 1 month. Central corneal thickness was also measured. A regression model was applied to compare OPA between the diagnostic groups. Results OPA increased with rising IOP (slope 0.026/0.033 and P=0.002/<0.0001 for Goldmann/Dynamic tonometry), whereas corneal thickness did not influence pulse amplitude measurements (slope−0.0017/−0.0013 and P=0.11/0.21 after correction for Goldmann/Dynamic tonometry). In a multivariate model correcting for IOP and corneal thickness, OPA was reduced in patients with NTG (P=0.014/0.017 corrected for Goldmann/Dynamic tonometry) or POAG (P=0.015/0.014). Conclusions OPA is reduced in normal tension and POAG patients compared with healthy controls. OPA is influenced by IOP, but not by corneal thickness. © 2008 Lippincott Williams & Wilkins, Inc.