Original StudiesAssociation of Central Corneal Thickness and 24-hour Intraocular Pressure FluctuationMosaed, Sameh MD*; Chamberlain, Winston Douglas MD, PhD*; Liu, John H. K. PhD†; Medeiros, Felipe A. MD, PhD†; Weinreb, Robert N. MD† Author Information *Department of Ophthalmology, University of California, Irvine †Department of Ophthalmology, Hamilton Glaucoma Center, University of California, San Diego, La Jolla, CA Reprints: Sameh Mosaed, MD, Department of Ophthalmology, University of California, 118 Med Surge I, Irvine, CA (e-mail: [email protected]). Received for publication September 11, 2006; accepted June 30, 2007 Journal of Glaucoma: March 2008 - Volume 17 - Issue 2 - p 85-88 doi: 10.1097/IJG.0b013e31814b9922 Buy Metrics Abstract Purpose To evaluate the association between office-hour central corneal thickness (CCT) and 24-hour intraocular pressure (IOP) fluctuation in patients with glaucoma. Design Observational case-control study. Methods Measurements of IOP were obtained every 2 hours during a 24-hour period from 52 untreated glaucoma patients and 29 age-matched normal control subjects housed in a sleep laboratory. Habitual IOP measurements were obtained using a pneumatonometer in the sitting positions during the diurnal/wake period (7 AM to 11 PM) and in the supine position during the nocturnal/sleep period (11 PM to 7 AM). CCT was measured in all subjects using ultrasound pachymetry once during office hours. The association between IOP fluctuation (peak IOP-trough IOP) during the 24-hour period and the office-hour CCT was assessed in both glaucoma patients and healthy age-matched controls using Spearman rank order correlation. Results There was no statistically significant correlation between IOP fluctuation and CCT in glaucomatous (P=0.405) and normal subjects (P=0.456). Conclusions Twenty-four–hour IOP fluctuations were not correlated with single CCT measurements taken during office hours in glaucoma patients. © 2008 Lippincott Williams & Wilkins, Inc.