Original StudiesComparison of Single Thickness and Double Thickness Processed Pericardium Patch Graft in Glaucoma Drainage Device Surgery A Single Surgeon Comparison of OutcomeLankaranian, Dara MD*; Reis, Ricardo MD*; Henderer, Jeffrey D. MD*; Choe, Sung MD†; Moster, Marlene R. MD*Author Information *William and Anna Goldberg Glaucoma Service, Wills Eye Hospital, Jefferson Medical College †Department of Ophthalmology, Temple University, Philadelphia, PA The authors have no financial interest in the material mentioned in the text. The study was unfunded. The study was done on the Glaucoma Service at Wills Eye Hospital/Jefferson Medical College. Reprints: Marlene R. Moster, MD, Wills Eye Hospital/Jefferson Medical College, 840 Walnut Street, Suite 1140, Philadelphia, PA 19107 (e-mail: [email protected]). Received for publication June 21, 2006; accepted June 2, 2007 Journal of Glaucoma: January 2008 - Volume 17 - Issue 1 - p 48-51 doi: 10.1097/IJG.0b013e318133fc49 Buy Metrics Abstract Purpose To compare the incidence of conjuctival erosions with single thickness versus double thickness allograft processed pericardium used in mitomycin-C (MMC) augmented glaucoma drainage device (GDD) sugery. Patients and Methods In a retrospective comparative case series, medical records of 84 consecutive glaucoma patients who underwent GDD surgery between July 1996 to December 2004 were reviewed. All surgeries were done by one glaucoma surgeon (M.R.M.). MMC was adminstered in all cases over the plate area and either single thickness processed pericardium patch graft (STPP) or double thickness processed pericardium patch graft (DTPP) was used to cover the external silicone tube of the glaucoma device at the limbus. The principal outcome measure was the incidence of conjunctival erosions associated with GDD surgery. Results Eighty-four patients (90 eyes) who met the eligibility criteria were enrolled in the study. Thirty-one consecutive eyes received a STPP, and 59 consecutive eyes received a DTPP. Five eyes (16.0%) in the STPP group developed conjunctival erosion. None of the eyes in DTPP group developed conjunctival erosion. The Mann-Whitney U test difference in the rate of conjunctival erosion was statistically significant between 2 groups (P=0.002). For the STPP group, the average time to conjunctival erosion was 9 months (range, 4 to 14 mo). All erosions were surgically corrected using DTPP and followed up for a mean of 8.6 months after repair with no additional conjunctival erosions. Conclusions DTPP placed over the silicone tube significantly reduced the incidence of conjunctival erosion after MMC augmented GDD surgery. © 2008 Lippincott Williams & Wilkins, Inc.