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Autoimmunity and Glaucoma

Grus, Franz H. MD, PhD; Joachim, Stephanie C. MD; Wuenschig, Diana Dipl. Biol.; Rieck, Jochen Dipl. Biol.; Pfeiffer, Norbert MD

doi: 10.1097/IJG.0b013e318156a592
Special Article
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Elevated intraocular pressure does not explain glaucoma in all patients, but there is information that autoimmune mechanisms may be involved in this disorder. This review attempts to reveal the findings about specific changes in autoantibody profiles in glaucoma patients and their possible role in glaucoma. Considering that these changes in natural autoimmunity can be found consistently among different study populations, it might be a promising new tool for glaucoma detection.

Experimental Ophthalmology, Department of Ophthalmology, Johannes Gutenberg University, Mainz, Germany

Reprints: Franz H. Grus, MD, PhD, Experimental Ophthalmology, Department of Ophthalmology, Johannes Gutenberg University, Langenbeckstrasse 1, 55101 Mainz, Germany (e-mail: grus@eye-research.org).

Received for publication February 12, 2007; accepted July 10, 2007

© 2008 Lippincott Williams & Wilkins, Inc.