Review ArticleOptic Nerve Restoration New PerspectivesBull, Natalie D. PhD; Martin, Keith R. MD FRCOphthAuthor Information Centre for Brain Repair, Cambridge University, UK Supported by The Glaucoma Research Foundation (San Francisco), Addenbrooke's Hospital Glaucoma Research Fund, GlaxoSmithKline Clinical Fellowship Program (K.R.M.). Reprints: Keith Martin, MD, FRCOphth, Cambridge University Centre for Brain Repair, Forvie Site, Robinson Way, Cambridge CB2 2PY, UK (e-mail: [email protected]). Received for publication August 2, 2006; accepted January 17, 2007 Journal of Glaucoma: August 2007 - Volume 16 - Issue 5 - p 506-511 doi: 10.1097/IJG.0b013e3180391a18 Buy Metrics Abstract Neural regeneration and repair in the central nervous system are currently hot topics in neuroscience. For many years there has been a hope that neurodegenerative diseases which are resistant to current therapies may be treated by the selective replacement of cells. Yet it is only recently that we have started to acquire the knowledge, tools, and techniques that may translate such optimism into new therapies. In this article, we will consider the potential to restore function to the damaged optic nerve. We will consider the technical issues involved and suggest a strategy for research progress. © 2007 Lippincott Williams & Wilkins, Inc.