FeaturesHealth-Related Quality of Life in Irritable Bowel Syndrome A Systematic Review and Meta-analysisCassar, Gillian E. DPsych; Youssef, George J. PhD, MPsych; Knowles, Simon PhD; Moulding, Richard PhD, MPsych; Austin, David W. DPsychAuthor Information Gillian E. Cassar, DPsych, School of Psychology, Deakin University, Geelong, Australia. George J. Youssef, PhD, MPsych, School of Psychology, Deakin University, Geelong, Australia; and The Centre for Adolescent Health, Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia. Simon Knowles, PhD, Faculty Health, Arts, and Design, Department of Psychology, Swinburne University of Technology, Melbourne, Australia; Department of Medicine, The University of Melbourne, Melbourne, Australia; Department of Psychiatry, St Vincent's Hospital, Melbourne, Australia; and Department of Gastroenterology and Hepatology, The Royal Melbourne Hospital, Melbourne, Australia. Richard Moulding, PhD, MPsych, School of Psychology, Deakin University, Geelong, Australia. David W. Austin, DPsych, School of Psychology, Deakin University, Geelong, Australia. Correspondence to: Gillian E. Cassar, DPsych, Faculty of Health, School of Psychology, Deakin University, Melbourne Burwood Campus, Level 5, Bldg BC, 221 Burwood Hwy, Burwood VIC, Australia 3125 (email@example.com). The authors declare no conflicts of interest. Supplemental digital content is available for this article. Direct URL citation appears in the printed text and is provided in the HTML and PDF versions of this article on the journal's website (www.gastroenterologynursing.com). Gastroenterology Nursing: May/June 2020 - Volume 43 - Issue 3 - p E102-E122 doi: 10.1097/SGA.0000000000000530 Buy SDC Metrics Abstract Irritable bowel syndrome (IBS) affects up to 20% of the global population and is associated with impaired health-related quality of life (HRQoL). This systematic review and meta-analysis aimed to investigate differences in HRQoL of those with IBS compared with healthy controls and to examine whether HRQoL improves following psychological intervention. Online databases were searched for articles from 2002 to 2017. Studies were screened and data extracted according to predetermined criteria. A total of 4,154 citations were identified from which 36 were eligible for inclusion. Eight studies compared HRQoL of those with IBS (n = 822) with that of healthy individuals (n = 3,809). Those with IBS suffered significant impairment across all HRQoL domains compared with healthy individuals, with the majority of effects (Cohen's d) being moderate to large. Twenty-eight studies investigated HRQoL in IBS following psychological intervention (n = 1,308) relative to controls (n = 1,006). All HRQoL domains improved with large effects following treatment; however, maintenance of these effects was inconsistent. Those with IBS experience poorer HRQoL than the wider community; nevertheless, psychological interventions are associated with improved HRQoL across all domains. High-quality studies are needed to better inform gastroenterological nurses of which interventions are most efficacious in alleviating the burden of IBS, and which IBS subpopulations would benefit. © 2020 Society of Gastroenterology Nurses and Associates.