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Medication Adherence Among Patients With Chronic Hepatitis Receiving Antiviral Treatment

Go, Hirofumi, MHlthSc, RN; Tanaka, Makoto, PhD, RN; Yamamoto-Mitani, Noriko, PhD, RN; Suzuki, Miho, PhD, RN; Kawakami, Aki, PhD, RN; Masaki, Naohiko, MD, PhD; Shimada, Megumi, PhD, RN

doi: 10.1097/SGA.0000000000000363
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This study aimed to evaluate medication adherence and associated factors among patients with chronic viral hepatitis. A cross-sectional questionnaire survey was conducted in 171 outpatients receiving antiviral treatment of chronic viral hepatitis at 6 national/regional liver disease treatment centers in Japan. Medication adherence was calculated as the subject-reported number of antiviral tablets taken in the past 2 weeks compared with the prescribed number of tablets. Subjects were divided according to 100% adherence or nonadherence. The impact of items pertaining to everyday experiences and perceptions regarding medication adherence were examined. Factors associated with medication adherence were identified via multiple logistic regression. The mean medication adherence rate was 95.8% ± 9.5% (range = 0%–100%), although a smaller proportion (95 subjects; 55.6%) was 100% adherent. Multiple logistic regression indicated a greater “lack of understanding of need for medication” (1 point: odds ratio (OR) = 1.51, 95% confidence interval (CI) [1.30, 1.76], p ≤ .01) and greater “restriction in life due to medication” (1 point: OR = 1.26, 95% CI [1.03, 1.54], p = 0.03) as associated with nonadherence. In conclusion, to improve medication adherence, healthcare professionals should improve patients' understanding of the need for medication and minimization of life restrictions.

Hirofumi Go, MHlthSc, RN, is Clinical Research Coordinator and Research Nurse, Department of Clinical Research, Center for Clinical Sciences National Center for Global Health and Medicine, Tokyo, Japan.

Makoto Tanaka, PhD, RN, is Professor, Department of Critical and Invasive–Palliative Care Nursing, Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

Noriko Yamamoto-Mitani, PhD, RN, is Professor, Department of Gerontological Home-Care & Long-term Care Nursing, Graduate School of Health Sciences & Nursing, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.

Miho Suzuki, PhD, RN, is Vice Director of Nursing, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.

Aki Kawakami, PhD, RN, is Project Assistant Professor, Department of Gerontological Home-Care & Long-term Care Nursing, Graduate School of Health Sciences & Nursing, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.

Naohiko Masaki, MD, PhD, is Medical Director, Laboratory Testing Department, National Center for Global Health and Medicine, Tokyo, Japan.

Megumi Shimada, PhD, RN, is Associate Professor, Department of Nursing Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan.

Correspondence to: Makoto Tanaka, PhD, RN, Department of Critical and Invasive–Palliative Care Nursing, Graduate School of Health Care Sciences, Tokyo Medical and Dental University, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8519, Japan (hmakoto-tky@umin.ac.jp).

The authors declare no conflicts of interest.

Received September 26, 2016

Accepted March 25, 2017

© 2019 by the Society of Gastroenterology Nurses and Associates, Inc.