The purpose of this study was to determine the interest level and needs of the Society of Gastroenterology Nurses and Associates (SGNA) to develop a research program for (SGNA), whose members care for patients with gastrointestinal (GI) problems. A questionnaire mailed to all members (3500) focused on their research interest and experience, and 358 questionnaires were returned (return rate 10%). Data were analyzed with descriptive statistics, analysis of variance, and content analysis. Educational levels were: 8% LPN, 32% RN, 16% AD, 31% BA/BS, 9% MA/MS. Sixty-seven percent were employed in GI endoscopy laboratories. Approx imately 35% had some type of research experience. The mean level of interest in research, rated on a scale of 0 (none) to 10 (high), was 6.6 (± 2.3). There was a significant difference between education and interest levels (RN and AD mean = 6.2, MS and “other” mean = 7.6). Moderate interest was expressed for all aspects of research (data collection—highest; finding funding—lowest). Two commonly expressed needs were for information about current GI research and how to begin the research process. The most frequently cited clinical problems needing study were infection control, staffing, and intraprocedure medication use and monitoring. This study demonstrated an interest in research among GI nurses of varied educational backgrounds and experience. Nurses in practice have observed many areas of concern and recognize the value of research to contribute to the improvement of their practice.