In 1955, Drs. Zollinger and Ellison described a triad of ailments which included severe ulcer disease, hypersecretion of gastric acid, and non-beta islet cell pancreas tumors. They proposed the syndrome to be the result of some humoral substance that stimulates gastric acid secretion. This theory was proved by Gregory and others. The “substance” eventually was identified as gastrin. Although many other features of the disease have been identified, the triad described remains the central form. In this article, we will discuss symptoms, diagnosis, and treatment of Z-E Syndrome, a treatment that has become controversial because of the discovery of histamine H2 receptor antagonists.
ABOUT THE AUTHOR. John Michael Haught, MD, is a graduate of the West Virginia University School of Medicine. He served his residency at the Charleston Area Medical Center, Charleston, West Virginia, and maintains a private practice in emergency medicine in Beckley, West Virginia. Dr. Haught is in his second year of a gastroenterology fellowship at Allegheny General Hospital, Pittsburgh, Pennsylvania.
The author wishes to thank Ms. Connie Cooper for her untiring efforts in editing his manuscript, and Ms. Marjorie Allison for typing it.
© The Society of Gastroenterology Nurses & Associates 1983. All Rights Reserved.