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The accuracy of flexible spectral imaging colour enhancement for the diagnosis of gastric intestinal metaplasia: do we still need histology to select individuals at risk for adenocarcinoma?

Kikuste, Ilzea,b; Stirna, Dansb; Liepniece-Karele, Intad; Leja, Mārcisa,b,c,e; Dinis-Ribeiro, Máriof,g

European Journal of Gastroenterology & Hepatology: July 2014 - Volume 26 - Issue 7 - p 704–709
doi: 10.1097/MEG.0000000000000108
Original Articles: Gastro-esophageal Disorders

Background Targeting biopsies on the basis of visual recognition of mucosal changes in the stomach instead of the currently accepted random biopsy sampling may be attractive.

Aim The aim of this study was to evaluate the accuracy of endoscopic findings using flexible spectral imaging colour enhancement (FICE) for intestinal metaplasia (IM) in the gastric mucosa.

Methods A consecutive cohort of 126 individuals aged over 50 years (27% men) was subjected to upper endoscopy using FICE. Histological assessment (per patient and per biopsy) was considered the gold standard to accuracy estimates.

Results Histological assessment revealed IM in 50% of the individuals [OLGIM (operative link on gastric intestinal metaplasia assessment) stages I–IV]. Overall, endoscopy presented sensitivities, specificities, positive likelihood ratio, negative likelihood ratio and accuracies per patient of 60% [95% confidence interval (95% CI) 48–72], 87% (95% CI 79–95), 4.7 (95% CI 2.4–93), 0.45 (95% CI 0.33–0.62) and 74% (95% CI 0.66–0.82), respectively, for IM diagnosis and 71% (95% CI 37–100), 87% (95% CI 79–95), 5.6 (95% CI 2.5–12.5), 0.32 (95% CI 0.10–1.0) and 86% (95% CI 77–94), respectively, for selecting individuals with OLGIM (III–IV). The proportions of agreement (and κ values) for IM in the antrum and the corpus were 75% (0.37) and 81% (0.19), respectively.

Conclusion FICE endoscopy yielded favourable results in the endoscopic diagnosis of IM of the gastric mucosa, and this is a very practical and easy method to use in daily clinical practice for unselected patients. Our study demonstrated a good specificity for FICE endoscopy to detect IM in the stomach. Further improvement in disseminating and training of this assessment is required to improve the reliability.

aFaculty of Medicine, University of Latvia

bDigestive Diseases Centre GASTRO

cDepartment of Research, Riga East University Hospital

dAcademic Histology Laboratory, SIA

eRiga East University Hospital, Riga, Latvia

fCINTESIS, Porto Faculty of Medicine

gDepartment of Gastroenterology, Portuguese Oncology Institute, Porto, Portugal

Correspondence to Ilze Kikuste, MD, University of Latvia, Linezera Street 6, Riga LV1006, Latvia Tel: +371 283 57349; fax: +371 670 40258; e-mail: ikikuste@gmail.com

Received February 10, 2014

Accepted March 18, 2014

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins