Review articleDiagnosis, surveillance, and treatment strategies for familial adenomatous polyposis: rationale and updateAihara, Hiroyuki; Kumar, Nitin; Thompson, Christopher C.Author Information Division of Gastroenterology and Hepatology, Brigham and Women’s Hospital, Boston, Massachusetts, USA Correspondence to Hiroyuki Aihara, MD, PhD, Division of Gastroenterology and Hepatology, Brigham and Women’s Hospital, 75 Francis St, Thorn 1404, Boston, MA 02115, USA Tel: +1 617 525 3109; fax, +1 617 264 6342; e-mail: [email protected] Received July 29, 2013 Accepted September 17, 2013 European Journal of Gastroenterology & Hepatology: March 2014 - Volume 26 - Issue 3 - p 255-262 doi: 10.1097/MEG.0000000000000010 Buy SDC Metrics Abstract Familial adenomatous polyposis is characterized by the development of multiple (>100) colorectal adenomas throughout the colorectum. This disorder can be caused by a germline mutation in the adenomatous polyposis coli gene and can be diagnosed either clinically or genetically. After diagnosis with the condition, patients should undergo prophylactic proctocolectomy with a neoreservoir, usually an ileoanal pouch, at an appropriate time. Individuals with a family history of this disease who have not been diagnosed should be advised to attend genetic counseling and to enroll in appropriate clinical and genetic surveillance programs. Recent progress in endoscopic technology, including high-resolution endoscopy, capsule endoscopy, and double-balloon endoscopy, has made possible more detailed and wide-ranging investigation of the gastrointestinal tract. Although there has been limited evidence, further studies on these new endoscopic technologies might alter the surveillance strategies for familial adenomatous polyposis. Copyright © 2014 Wolters Kluwer Health, Inc. All rights reserved.