Original Articles: Liver Diseases–GeneticsA new genetic variant involved in genetic susceptibility to alcoholic liver cirrhosis: −330T>G polymorphism of the interleukin-2 geneMarcos, Miguela; Pastor, Isabela b; González-Sarmiento, Rogeliob; Laso, Francisco-JavieraAuthor Information aAlcoholism Unit, Service of Internal Medicine, University Hospital of Salamanca bMolecular Medicine Unit, Department of Medicine. University of Salamanca, Salamanca, Spain Correspondence to Francisco-Javier Laso, Service of Internal Medicine, University Hospital of Salamanca, Paseo de San Vicente 58-182, 37007, Salamanca, Spain Tel: +34 923291437; fax: +34 923294739 e-mail: firstname.lastname@example.org Received 2 January 2008 Accepted 14 February 2008 European Journal of Gastroenterology & Hepatology: September 2008 - Volume 20 - Issue 9 - p 855-859 doi: 10.1097/MEG.0b013e3282fd0db1 Buy Metrics Abstract Objective Genetic factors may determine susceptibility to develop alcoholic liver cirrhosis, although it remains uncertain why only a minority of alcoholics suffers from this disease. A decrease in serum levels of interleukin-2 (IL-2) is usually found in alcoholic cirrhotics. In this study we examined the relationship between the −330T>G IL-2 gene (IL2) polymorphism and alcoholic liver cirrhosis. Methods Genotyping of the aforementioned polymorphism was done by polymerase chain reaction and digestion with restriction enzymes in 257 male alcoholics (161 without liver disease and 96 with alcoholic liver cirrhosis) and 101 healthy controls. A logistic regression analysis was performed to adjust for potential confounders and to analyze the model of inheritance. Results We found an association between the −330T>G IL2 polymorphism and alcoholic liver cirrhosis: the frequency of the allele T carriers (genotype TT and GT) was significantly higher in alcoholics with cirrhosis (96.9%) than in those without liver disease (89.4%, P=0.043). Conclusion We report for the first time that the possession of the −330T allele of the IL2 is associated with a higher risk of developing alcoholic liver cirrhosis and this fact may favor the progression of alcoholic liver disease. © 2008 Lippincott Williams & Wilkins, Inc.