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Nonalcoholic fatty liver disease decrease in obese adolescents after multidisciplinary therapy

Tock, Lian; Prado, Wagner L.; Caranti, Danielle A.; Cristofalo, Dejaldo M.J.; Lederman, Henrique; Fisberg, Mauro; Siqueira, Kãli O.; Stella, Sérgio G.; Antunes, Hanna K.; Cintra, Isa P.; Tufik, Sérgio; Túlio de Mello, Marco; Dâmaso, Ana R.

European Journal of Gastroenterology & Hepatology: December 2006 - Volume 18 - Issue 12 - p 1241-1245
doi: 10.1097/01.meg.0000243872.86949.95
Original Articles: Liver Diseases

Background Despite the increasing prevalence of nonalcoholic fatty liver disease, its pathogenesis and clinical significance remain poorly defined and there is no ideal treatment.

Objective The aim of this study was to assess the short-term (12-week) multidisciplinary therapy on visceral adiposity and nonalcoholic fatty liver disease control.

Methods We evaluated and compared the distribution of visceral adiposity and nonalcoholic fatty liver disease, by ultrasonography, in 73 post-puberty obese participants (17.01±1.6 years old; body mass index 36.54±2.86 kg/m2), submitted to a multidisciplinary treatment without medications, at the beginning and after 12 weeks of intervention. Descriptive and one-way analysis of variance, and paired t-test were performed.

Results The results indicated that after intervention the adolescents had a significant reduction in visceral adiposity (4.05±1.55 to 3.37±1.44) and nonalcoholic fatty liver disease prevalence (from 52 to 29% on the right side and from 48 to 29% on the left side). It is a positive result because nonalcoholic fatty liver disease can progress to cirrhosis, even in children and adolescents.

Conclusions The short-term treatment suggests a profound impact on the control of obesity-related co-morbidities in young people.

Federal University of São Paulo, Paulista Medicine School, UNIFESP, EPM, São Paulo, Brazil

Correspondence and requests for reprints to Ana R. Dâmaso, Rua Marselhesa no. 535, Vila Clementino 04020-060 São Paulo/SP, Brazil

Tel/fax: +5511 5572 0177; e-mail:

Sponsorship: The CEPE/CAAA Multidisciplinary Obesity Intervention Program was supported by AFIP, FAPESP and CNPq.

Received 7 March 2006 Accepted 17 June 2006

© 2006 Lippincott Williams & Wilkins, Inc.