Objective
To study the relationship between daily alcohol consumption and the result of eradication therapy for Helicobacter pylori using omeprazole, clarithromycin and amoxicillin for 1 week.
Design
Clinical trial.
Setting
Urban health centre, general medicine section.
Participants
One hundred and fifty-six patients with a diagnosis of peptic ulcus or chronic gastritis. Helicobacter pylori infection was confirmed by the urease test, the 14C-urea breath test, IgG serology or biopsy.
Interventions
A combination of omeprazole, 20 mg twice daily, clarithromycin, 500 mg twice daily, and amoxicillin, 1000 mg twice daily was administered for 1 week. No other drugs were given. Four to 8 weeks later a 14C-urea breath test was carried out to confirm eradication.
Main outcome measures
Logistic regression was used to assess the relationship between eradication and daily alcohol consumption (main covariable), age, sex, smoking, length of illness, pathology studied (ulcus or gastritis) and therapeutic compliance.
Results
Eradication (intention to treat analysis) was successful in 118 patients (75.6%; 95% CI, 68.9–82.4). The only variable significantly associated with the result of the therapy was daily alcohol consumption, with a higher probability of failure in non-consumers (29.9%) than in consumers (12.2%), adjusted OR 3.24 (95% CI, 1.12–9.20;P = 0.03). Eradication was dose dependent: 70.1% in abstemious patients (n = 107), rising to 79.3% in users of 4–16 g of pure ethanol a day (n = 29) and to 100% in users of 18–60 g daily (n = 20) with a P value of 0.005 for the trend.
Conclusions
Daily alcohol consumption appears to have an additive effect in this eradication therapy.
