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Understanding the mechanisms of paracentesis-induced circulatory dysfunction

Sola-Vera, Javiera; Such, Joséb

European Journal of Gastroenterology & Hepatology: March 2004 - Volume 16 - Issue 3 - p 295-298
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Paracentesis-induced circulatory dysfunction is a clinically relevant complication of large-volume paracentesis.

Paracentesis-induced circulatory dysfunction is related to an accentuation of arteriolar vasodilatation, already present in patients with advanced cirrhosis.

• The origin of arteriolar vasodilatation occurring after paracentesis is probably multifactorial and includes the dynamics of paracentesis, increased synthesis of nitric oxide from the vascular endothelium and mechanical changes secondary to mechanical decompression.

• Although, to date, plasma volume expanders are the only effective treatment for the prevention of paracentesis-induced circulatory dysfunction, other approaches are under evaluation.

Large-volume paracentesis induces early beneficial haemodynamic changes that may be shortly followed by a disorder known as paracentesis-induced circulatory dysfunction, characterized by a marked activation of the renin–angiotensin axis. Evidence is accumulating however that this disorder is secondary to an accentuation of an already established arteriolar vasodilatation. The causes of this syndrome are probably multiple and may include the dynamics of paracentesis (the rate of ascitic fluid extraction), release of nitric oxide from the vascular endothelium and mechanical modifications due to abdominal decompression. Patients developing this syndrome are prone to a faster reaccumulation of ascites, renal impairment and shorter survival. Plasma volume expansion after paracentesis reduces the incidence of this disorder. Preliminary evidence suggests that other approaches, such as the use of splanchnic vasoconstrictors or modulating the rate of ascitic fluid extraction, could be also effective, although more studies are needed.

aDepartment of Gastroenterology, Hospital Universitario de Elche and bLiver Unit, Hospital General Universitario, Alicante, Spain.

Sponsorship: This work was supported in part by Instituto de Salud Carlos III (03/02).

Correspondence to José Such MD, Liver Unit, Hospital General Universitario, c/Pintor Baeza s/n, 03010 Alicante, Spain. Tel: +34 965938345; fax: +34 965938355; e-mail: such_jos@gva.es

Received 26 June 2003

Large-volume paracentesis is widely used for the treatment of ascites in cirrhosis. Several randomized trials have shown that it is more effective than diuretics, and is associated with a lower rate of complications and reduced length of hospitalization [1,2]. However, the removal of large amounts of ascitic fluid may induce an impairment of circulatory function that has been termed paracentesis-induced circulatory dysfunction (PICD), first described by Ginès et al. [3]. They observed that most patients treated by large-volume paracentesis without associated infusion of plasma expanders developed a circulatory disorder characterized by marked activation of vasoactive systems, namely plasma renin activity (PRA) and plasma aldosterone concentration. Since then, several studies have investigated the mechanisms leading to the development of PICD but, to date, the origin of this disorder is only partially understood.

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Why is PICD relevant?

PICD is a prevalent disorder, appearing in up to 80% of cases when paracentesis is performed without subsequent plasma volume expansion [3]. It consists of a persistent deterioration of the circulatory status that is diagnosed through PRA variations [4]. Soon after large-volume paracentesis, important haemodynamic changes affecting the renin–angiotensin axis may develop. Accordingly, the sensitivity of PRA levels for the diagnosis of PICD 2 days after paracentesis is low [5]; PICD is best defined by an elevation of PRA of more than 50% to >4 ng/ml/h on the fifth to sixth day after paracentesis.

Some authors consider PICD to be just a ‘cosmetic disturbance’ because it is clinically silent. In fact, few patients show serious clinical complications in the short term, but those developing PICD have a tendency to reaccumulate ascitic fluid faster and to develop hyponatraemia and functional renal failure [5]. Moreover, PICD is not spontaneously reversible and patients who develop this disorder show a reduced survival [5].

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Early haemodynamic changes induced by paracentesis

Characteristic haemodynamic changes following paracentesis begin after removal of as little as 250 ml ascitic fluid [6] and consist of a marked decrease in right atrial and pulmonary pressures, a decrease in mean arterial pressure, an increase in cardiac output and systemic vasodilatation [4,7–11]. Modifications of the neurohumoral profile are also seen immediately after paracentesis, namely a reduction in PRA and aldosterone levels and an increase in atrial natriuretic peptide (ANP) [4,7,10].

There is no question that most of these changes are favourable overall: an increase in cardiac output, systemic vasodilatation and deactivation of the renin–angiotensin–aldosterone axis reduce fluid retention and favour organ perfusion, thereby alleviating two symptoms that negatively characterize cirrhotic patients with ascites. However, these changes are not maintained indefinitely if large-volume paracentesis is not followed by plasma expansion. Indeed, from 3–24 h after paracentesis, a picture consistent with hypovolaemia develops [7], being characterized by significant reductions in cardiac index, pulmonary pressures and ANP together with significant increases in PRA and plasma aldosterone concentration [4].

Initially, some authors proposed that PICD could be caused by a decrease in the total circulating blood volume secondary to a rapid reaccumulation of ascites. However, several studies failed to demonstrate a significant reduction in intravascular volume after removal of large volumes of ascitic fluid [4,12]. Also, in a study by Saló et al. [13], the plasma volume and transvascular escape of albumin (that estimates the net leakage of fluid from the intravascular compartment to the interstitial fluid) were measured in cirrhotic patients with tense ascites before and 48 h after total paracentesis. PICD occurred in the absence of changes in any of these measures.

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How can early haemodynamic changes be explained?

Since plasma volume remains unchanged, an accentuation of arterial vasodilatation, which is already present in patients with advanced cirrhosis, has been suggested to explain the early decrease of systemic vascular resistance (SVR) that develops shortly after paracentesis. The question is why the mobilization of large volumes of ascitic fluid can induce arteriolar vasodilatation. Three pathogenic mechanisms may be considered. In this issue of the Journal, Coll et al. [14] show that the dynamics of paracentesis constitute an important factor that can influence the early decrease of SVR. The authors report that patients in whom a decrease of SVR (as measured by echo-Doppler) after large-volume paracentesis was observed showed higher baseline intra-abdominal pressure (IAP), together with a shorter duration of paracentesis and higher flow rate of ascites extraction. However, the total volume of ascites drained did not differ between patients who developed a decrease in SVR and those who did not. This is not surprising since other factors, such as abdominal wall compliance, can determine the IAP. An interesting finding of the study by Coll et al. [14] is the significant correlation found between serum values of nitric oxide metabolites and SVR. The authors suggest that an increase in the synthesis of nitric oxide in response to ‘shear stress’ induced by the increased cardiac output that occurs after paracentesis may be intimately related to post-paracentesis arteriolar vasodilatation.

From a different point of view, it has been suggested that changes in SVR occurring after paracentesis can be explained by mechanical factors. Cabrera et al. [15] designed a special pneumatic girdle to maintain a constant IAP during paracentesis. When IAP was maintained at its original level, no haemodynamic changes were observed but a significant decrease in SVR appeared immediately after girdle deflation. The authors suggested that the abrupt decrease in IAP after paracentesis induces a deleterious effect due to mechanical decompression of an already dilated splanchnic vascular bed in patients with hypo-responsiveness to vasoconstrictors [16–18]. The beneficial haemodynamic effects derived from changes in cava vein pressure after paracentesis initially hide the deleterious effects of abdominal decompression on the splanchnic vascular bed, which only emerge when the former effect is exhausted.

A third hypothesis is that reduction in SVR is a reflex of the stimulation of cardiac-volume receptors inhibiting sympathetic vasoconstrictor tone and renal release of renin via an increase in cardiac volume [7]. The increase in heart volume as a consequence of increased pre-load after paracentesis may also be directly responsible for the increase in ANP seen immediately after paracentesis.

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What do we know about the mechanisms of PICD?

We cannot conclude from these data that the dynamics of paracentesis, release of nitric oxide or a reflex cardiogenic mechanism are the cause of PICD appearing 5–6 days after paracentesis, as the above-mentioned studies were designed to investigate only the early decrease in SVR after paracentesis. Only two studies have been designed to assess the mechanisms of PICD. Ruiz-del-Arbol et al. [19] observed that most haemodynamic changes occurring immediately after completion of paracentesis persisted 6 days after the procedure, despite expansion with dextran 70. Although cardiac index returned to baseline levels at the sixth day, cardiopulmonary pressures and SVR continued to be significantly reduced with respect to pre-treatment values. Because at this time most patients had less ascitic fluid than before paracentesis, the lower cardiopulmonary pressures could be attributed to a lower intrathoracic pressure. The magnitude of the reduction in SVR 6 days after paracentesis was greater in patients developing PICD, and the reduction occurred in spite of a recovery of cardiac index. This finding suggests that other mechanisms, independent of cardiac output, may be implicated in PICD. The authors also observed a significant inverse correlation between changes in SVR and the degree of activity of renin–angiotensin and the sympathetic nervous system: patients with greater increases in PRA and plasma norepinephrine levels had more intense peripheral vasodilatation.

Similarly, Vila et al. [20] reported an inverse correlation between PRA and plasma aldosterone concentration and SVR calculated by echo-Doppler. Patients developing PICD showed a significant reduction in SVR 6 days after paracentesis, while those who did not develop PICD showed no change in SVR.

Taken together, these observations suggest that PICD is caused by a further arteriolar vasodilatation and that stimulation of the renin–aldosterone and sympathetic nervous systems corresponds to compensatory mechanisms to maintain circulatory homeostasis. Although more studies designed to investigate the mechanism of PICD are needed, a hypothesis to explain PICD may be formulated as follows. Immediately after paracentesis, an effective hypovolaemia due to accentuation of arteriolar vasodilatation occurs. The origin of this vasodilatation is probably multifactorial and includes an abrupt decrease in IAP, a reflex mechanism via the increase in cardiac output and an increased release of nitric oxide, likely to be secondary to shear stress. In response to this vasodilatation, activation of the renin–angiotensin and sympathetic nervous systems takes place. Patients who are able to compensate for this vasodilatation in the first few days after paracentesis will not develop PICD and the levels of PRA will return to baseline. However, PICD will develop in those who are unable to compensate. The degree of hyporesponsiveness to vasoconstrictors could play an important role in this setting.

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What can we do to prevent PICD?

No significant haemodynamic or hormonal variations were reported up to 48 h after paracentesis when a low volume of ascitic fluid was evacuated (≤ 5 l) [21]. In addition, the volume of ascites has been related to the incidence of PICD in two studies [5,22]. Therefore, reducing the volume of ascites drained seems an effective measure to prevent PICD, but might prolong hospitalization in patients with large volumes of ascitic fluid.

The data of Coll et al. [14] reported in this issue of the Journal suggest a new approach to this problem. If confirmed in appropriate studies, reducing the flow rate of extraction of ascitic fluid could represent a low-cost, useful tool to decrease the incidence of PICD. Other measures, such as placing a pneumatic girdle during paracentesis, need further evaluation.

Plasma volume expanders have been shown to be effective in the prevention of PICD. As outlined above, the incidence of PICD reaches 80% when large-volume paracentesis is performed without additional therapeutic measures, and can be reduced to 15–35% when plasma volume expanders are used. The efficacy of each substance is related to its plasma half-life, those with a longer half-life being the most effective. The rationale for using plasma expanders after paracentesis is to refill the dilated vascular space after paracentesis, thereby preventing the subsequent activation of vasoconstrictor systems.

As outlined above, the incidence of PICD can be reduced to 15% when albumin is used as a plasma expander after paracentesis [23], and this is probably related to its prolonged half-life (21 days). However, albumin has disadvantages including its high cost and the suggestion that its use may be harmful in some cases [24]. Other plasma expanders have been shown to be effective in the prevention of PICD: dextran 70 is a polysaccharide consisting of a mixture of glucose molecules with different molecular weight fractions ranging between 15 000 and 160 000 Da, with an elimination half-life of 24–48 h [25]; polygeline is a synthetic, polymerized gelatine with a half-life of 4 h; and saline solution is another short-life plasma expander that has been used after paracentesis. Several studies initially showed that these substances might represent a valid alternative to albumin, as the incidences of renal failure, complications and PRA variations encountered were similar to those experienced with albumin use, and they had the important advantage of being less costly [23,26–28]. However, a recent, large, randomized trial showed that albumin was better than dextran 70 and polygeline in the prevention of PICD [5]. Furthermore, a recent randomized trial performed by our group [22] has shown that the incidence of PICD is significantly lower in patients receiving albumin than in those receiving saline. However, albumin was better than other plasma expanders only when a large volume of ascites was drained. In contrast, when a low volume of ascitic fluid was evacuated the incidence of PICD was low (about 10%) irrespective of the type of plasma expander used.

If paracentesis-induced arteriolar vasodilatation precedes and plays a major role in the development of decreased effective arterial blood volume, the administration of a splanchnic vasoconstrictor might be effective in the prevention of PICD. In a pilot study [29], 20 patients with tense ascites were randomly assigned to be treated with paracentesis plus terlipressin, a potent splanchnic vasoconstrictor, or paracentesis plus albumin. Terlipressin was administered as an intravenous 1 mg bolus at the onset of paracentesis and then 8 h and 16 h after the first bolus. No significant variations in plasma renin concentrations were observed irrespective of the treatment group and changes in baseline plasma renin concentrations did not differ between the terlipressin and albumin groups. However, because of the small sample size of the study group, a type II error cannot be excluded.

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Conclusions

PICD is a clinically relevant complication of paracentesis. Despite initial studies suggesting that PICD was related to a decrease of total blood volume, there is now evidence that accentuation of arteriolar vasodilatation is the origin of this disorder. More studies designed to investigate PICD are needed. Plasma volume expansion is the only proven treatment to prevent the condition. More studies are needed to clarify the work of other therapeutic approaches, as detailed here, in the prevention of this disturbance.

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Conflict of interest

None declared.

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Keywords:

decompensated cirrhosis; ascitic fluid; paracentesis-induced circulatory dysfunction; renal impairment; paracentesis; vasoactive systems

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