ReviewsOral manifestations of inflammatory bowel disease: the neglected piece of the puzzleSbeit, Wisama,,b; Kadah, Anasa,,b; Mahamid, Mahmudc; Karayanni, Halad; Mari, Amire; Tali, Shanid; Srouji, Samerd; Khoury, Tawfika,,bAuthor Information aDepartment of Gastroenterology, Galilee Medical Center, Nahariya bFaculty of Medicine in the Galilee, Bar-Ilan University, Safed cFaculty of medicine, Hebrew University of Jerusalem, Department of Gastroenterology, Shaare Zedek Medical Center, Jerusalem, Israel dOral and Maxillofacial Department, Medical Center, Nahariya, The Azrieli Faculty of Medicine, Bar-Ilan University, Ramat Gan eGastroenterology and endoscopy units, The Nazareth Hospital, EMMS, Nazareth, Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel Received 22 July 2020 Accepted 8 August 2020 Correspondence to Tawfik Khoury, MD, Department of Gastroenterology, Galilee Medical Center, Nahariya, Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel, Tel: +972 509870611; e-mail: [email protected] European Journal of Gastroenterology & Hepatology: November 2020 - Volume 32 - Issue 11 - p 1422-1431 doi: 10.1097/MEG.0000000000001918 Buy Metrics Abstract Inflammatory bowel disease (IBD) is a chronic relapsing remitting autoimmune disease including Crohn’s disease and ulcerative colitis. IBD is associated with various extra-intestinal manifestations including oral manifestation. To date, only limited studies addressing the characteristics of the oral manifestations are available. The aim of the present review is to report the oral manifestations and their characteristics in IBD. A Medline/PubMed and Embase databases search were conducted and all relevant studies were extracted and analyzed. Overall, the oral manifestations in IBD were mostly associated with Crohn’s disease rather than Ulcerative colitis where their prevalence ranged from 8 to 50%. Specific lesions for Crohn’s disease include mucosal tags, cobblestoning and deep linear ulcerations with vertical fissures, while for ulcerative colitis, pyostomatisis vegetans was more disease specific. Notably, most of the oral manifestations were unrelated to disease activity, however more data are needed to accurately assess this correlation. Oral manifestations among IBD patients are not uncommon as Crohn’s disease account for most of them. More data are warranted to precisely characterize their prevalence and association to intestinal activity. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.