Review ArticlesNon-alcoholic fatty liver disease in inflammatory bowel disease patientsKaraivazoglou, Katerinaa; Konstantakis, Christosb; Tourkochristou, Evanthiab; Assimakopoulos, Stelios F.c; Triantos, ChristosbAuthor Information aDepartment of Psychiatry, University Hospital of Patras bDivision of Gastroenterology, Department of Internal Medicine, University Hospital of Patras cDepartment of Internal Medicine, University Hospital of Patras, Rio, Greece Received 11 August 2019 Accepted 5 November 2019 Correspondence to Christos Triantos, MD, PhD, University Hospital of Patras, Rio 26500, Greece, Tel: +00306972894651; fax: +00306972894651; e-mail: firstname.lastname@example.org European Journal of Gastroenterology & Hepatology: August 2020 - Volume 32 - Issue 8 - p 903-906 doi: 10.1097/MEG.0000000000001679 Buy Metrics Abstract Non-alcoholic fatty liver disease is a highly prevalent medical condition, characterized by intrahepatic fat accumulation which may eventually lead to hepatic inflammation, cell death and reactive fibrosis. Obesity and metabolic disturbances constitute significant contributors to liver steatosis pathogenesis, however, there is a growing awareness that fatty liver may emerge even in normal weight or metabolically healthy individuals. In recent years, advanced imaging techniques have revealed that liver steatosis is quite common in inflammatory bowel disease patients, suggesting that intestinal inflammation and disturbances of the liver-gut axis may also play a key role in non-alcoholic fatty liver disease pathophysiology. The current review focuses on the co-occurrence of the two disorders, integrating research findings on epidemiology, clinical characteristics and common pathophysiological processes. The study of liver steatosis in inflammatory bowel disease patients may provide useful insights on the complex links between dietary fat intake, metabolic dysregulation, gut physiology and intrahepatic cellular mechanisms underlying liver inflammation and damage. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.