The primary objective was to examine the trends in treatment modalities and the respective survival rates for esophageal cancer in the province of Ontario, Canada.
This is a population-based study of all esophageal cancer cases diagnosed in Ontario between 2007 and 2015, including squamous cell carcinoma and adenocarcinoma, with known disease stage. Other characteristics include sex, age, date of diagnosis, and treatment modalities. Treatment modalities were classified as no-treatment, radiation only or chemotherapy only, chemoradiation, and surgical resection.
In total, 2572 patients were identified with esophageal cancer from 2007 to 2015, of which 2014 (78.3%) were male. The mean age at diagnosis was 66.6 (SD = 11.7) years. Survival rate increased over time in patients who underwent chemoradiation or surgical resection but remained unchanged for the radiation-only or chemotherapy-only group and decreased for the no-treatment group. Survival considerably improved (15–20%) for patients with stages I–III disease.
The positive trends in the survival rate for esophageal patients could be due to adoption of multimodal therapy. Despite a lower proportion of advanced disease among patients over 80, they received less curative treatments compared with other age groups. Further studies are required to identify strategies to maximize survival for patients with stage IV disease, and patients 80 years and older.
aSchool of Nursing, McMaster University, Hamilton
bDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton
cSchool of Medicine, University of Toronto, Toronto
dDepartment of Oncology, McMaster University, Hamilton
eDepartment of Surgery, McMaster University, Hamilton
fDivision of Thoracic Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada
Received 11 March 2019 Accepted 14 May 2019
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Correspondence to Noori Akhtar-Danesh, PhD, School of Nursing, McMaster University, 1280 Main St. West, Room 3N28B, Hamilton, ON L8S 4K1, Canada, Tel: +905 525 9140 x22297; fax: +905 521 8834; e-mail: email@example.com