Review ArticlesHepatocellular carcinoma in the noncirrhotic liver: a literature reviewZhang, Yanana; Wang, Chunguangb; Xu, Hongqina; Xiao, Penga; Gao, YanhangaAuthor Information aDepartment of Hepatology, The First Hospital of Jilin University bDepartment of Thoracic Surgery, The Second Hospital of Jilin University, Changchun, Jilin China Correspondence to Yanhang Gao, Department of Hepatology, The First Hospital of Jilin University, 71 Xinmin Avenue, Changchun, Jilin 130021, China Tel: +86 158 0430 3019; fax: +86 431 8878 5113; e-mail: firstname.lastname@example.org European Journal of Gastroenterology & Hepatology: July 2019 - Volume 31 - Issue 7 - p 743-748 doi: 10.1097/MEG.0000000000001419 Buy Metrics Abstract Development of hepatocellular carcinoma (HCC) is usually preceded by chronic liver injury and ongoing liver diseases. Liver cirrhosis reflects the outcome of long-term liver injury and is associated with an increased risk of developing HCC. However, HCC also arises in individuals without cirrhosis and bears several characteristics distinct from HCC in the cirrhotic liver. The molecular characteristics, prognosis, and surveillance of noncirrhotic HCC have not been adequately studied. In this review, we update readers and researchers in the field with the latest understanding of the epidemiology, etiology, clinical features, diagnosis, treatment strategies, prognosis, and surveillance of noncirrhotic HCC. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.