Gastric varices (GV) manifest in almost one-fifth of the patients with portal hypertension. Although primary pharmacological prevention of esophageal varices has been identified, there are limited therapeutic options that are optimal for GV bleeding. Recently, the use of endoscopic ultrasound (EUS)-guided angiotherapy [cyanoacrylate (CA) and coils] was introduced for the treatment of GV. Although CA injection is the recommended first-line therapeutic modality, it is associated with systemic, life-threatening embolization as well as technical instrumental challenges. Recently, EUS-guided coiling for GV was used with high safety profile.
This is a review of the current literature on the treatment of GV, focusing on the role of EUS-guided angiotherapy in the treatment of GV. We performed a Medline/PubMed search, and 37 relevant studies were extracted and examined.
EUS-guided angiotherapy has shown a consistent favorable result among the several reports throughout the literature, with better safety and efficacy profile toward EUS-guided coiling; however, a combination treatment with EUS-guided coiling followed by glue injection has shown as well to reduce the embolization adverse events associated with glue injection.
EUS-guided angiotherapy and specifically EUS-guided coiling is an emerging promising technique and should be considered as a first-line therapeutic option for bleeding GV.
aDepartment of Internal Medicine
bLiver Unit, Department of Gastroenterology, Hadassah Hebrew University Medical Center, Ein Kerem, Jerusalem
cGastroenterology and Endoscopy United, The Nazareth Hospital, EMMS, Nazareth, Israel
dInternal Medicine Department, Division of Gastroenterology, Center for Advanced Endoscopy, University of South Alabama, Mobile, Alabama, USA
Correspondence to Tawfik Khoury, MD, The Liver Unit, Division of Internal Medicine, Institute of Gastroenterology and Liver Diseases, Hebrew University-Hadassah Medical Center, PO Box 12000, 91120 Jerusalem, Israel Tel: +972 509 870 611; fax: +972 4957 5832; e-mails: email@example.com, firstname.lastname@example.org
Received March 14, 2018
Accepted April 27, 2018