Previous studies have shown a close relationship between Helicobacter pylori (H. pylori), insulin resistance, and altered metabolic parameters. However, the effects of H. pylori eradication on these conditions remain controversial. We carried out a systematic review and meta-analysis to evaluate the effects of H. pylori eradication on insulin resistance and metabolic parameters.
We searched CENTRAL, MEDLINE, and EMBASE databases from their inception to July 2016. Insulin resistance (HOMA-IR), body weight (BW), BMI, waist circumference, triglycerides (TG), high-density and low-density lipoprotein-cholesterol (HDL-C and LDL-C), and fasting blood glucose (FBG) were compared between patients with and without H. pylori eradication using a random-effects model. We reported pooled mean differences (MD) and 95% confidence intervals (CI) for the change in outcomes.
Data from five studies showed no difference in HOMA-IR after H. pylori eradication (pooled MD=−0.52, 95% CI: −1.47 to 0.42). Eradication significantly increased BMI (MD=0.36, 95% CI: 0.11–0.60) and BW (MD=1.1, 95% CI: 0.8–1.5), but had no significant effects on TG, LDL-C, HDL-C, or FBG.
H. pylori eradication does not improve insulin resistance, TG, HDL-C, LDL-C, or FBG, but may increase BW and BMI. Further studies are needed to clarify the effect of H. pylori eradication on metabolism.
Supplemental Digital Content is available in the text.
aDepartment of Internal Medicine, Bassett Medical Center, Columbia University College of Physicians and Surgeons, Cooperstown, New York
bDepartment of Internal Medicine, University of Hawaii, Honolulu, Hawaii, USA
cDepartment of Preventive and Social Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Salaya
dDepartment of Internal Medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand
Correspondence to Veeravich Jaruvongvanich, MD, Department of Internal Medicine, University of Hawaii, 1511 Nuuanu Ave, Honolulu, Hawaii 96817, USA Tel: +1 808 542 1939; fax: +1 808 586 7486; e-mail: firstname.lastname@example.org
Received July 16, 2016
Accepted September 15, 2016