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Short article

Remicade infusions at home

an alternative setting of infliximab therapy for patients with Crohn’s disease

Kuin, Sabine; Stolte, Suzan B.; van den Brink, Gijs R.; Ponsioen, Cyriel Y.; Fockens, Paul; D’Haens, Geert R.; Löwenberg, Mark

European Journal of Gastroenterology & Hepatology: February 2016 - Volume 28 - Issue 2 - p 222–225
doi: 10.1097/MEG.0000000000000530
Original Articles: Inflammatory Bowel Disease
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Objective Infliximab maintenance treatment for Crohn’s disease (CD) consists of intravenous infusions that are usually given at 6–8-week intervals. We aimed to evaluate whether home-based infliximab infusions could offer a useful and safe alternative for the management of CD patients.

Methods Adult CD patients receiving infliximab maintenance treatment at the Academic Medical Center in Amsterdam were invited to receive their infusions at home for the duration of 1 year. Patients had to be in clinical remission and should have had no adverse events during previous infusions. Patient satisfaction and experience were studied. Costs were analyzed and compared with hospital-based infliximab infusions.

Results Twenty-nine patients were invited, of whom 13 (45%) wanted to participate. Of the participants, 54% were female, and the median age was 33 years. In total, 59 infliximab infusions were administered at home at a median dose of 360 mg. The median rating of patient satisfaction was 8 on a scale from 1 to 10 for both home and hospital treatment settings. An important observation was that patients’ willingness to participate would have been 70% if the possibility of receiving infusions at home outside office hours had been offered. Costs of infliximab infusions at home were €229 per infusion compared with €284 at the infusion clinic (excluding drug costs).

Conclusion Home-based infliximab infusions were associated with a cost saving of €55 per infusion. Most participants were satisfied and would recommend home-based infusions to others. Infliximab treatment at home might be recommended as routine care for CD patients.

Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands

Correspondence to Mark Löwenberg, MD, PhD, Department of Gastroenterology and Hepatology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands Tel: +31 20 566 7621; fax: +31 20 691 7033; e-mail: m.lowenberg@amc.uva.nl

Received August 24, 2015

Accepted October 19, 2015

Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.