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Short-term probiotic therapy alleviates small intestinal bacterial overgrowth, but does not improve intestinal permeability in chronic liver disease

Kwak, Dong Shina; Jun, Dae Wona; Seo, Jae Gub; Chung, Won Seokb; Park, Soon-Eungb; Lee, Kang Nyeonga; Khalid-Saeed, Waqara; Lee, Hang Laka; Lee, Oh Younga; Yoon, Byung Chula; Choi, Ho Soona

European Journal of Gastroenterology & Hepatology: December 2014 - Volume 26 - Issue 12 - p 1353–1359
doi: 10.1097/MEG.0000000000000214
Original Articles: Liver Failure

Aim: Although numerous animal studies suggest that probiotic therapy has beneficial effects in various liver diseases, the evidence for beneficial effects in human liver disease is controversial. This study was carried out to investigate the efficacy of probiotic therapy in alleviating small intestinal bacterial overgrowth (SIBO) and permeability in chronic liver disease.

Methods: Fifty-three patients with chronic liver disease were randomized to either probiotic therapy or placebo. Six bacterial species were used: Bifidobacterium bifidum, Bifidobacterium lactis, Bifidobacterium longum, Lactobacillus acidophilus, Lactobacillus rhamnosus, and Streptococcus thermophilus. After 4 weeks, changes in the composition of fecal bacteria, SIBO, intestinal permeability, and clinical symptoms were examined.

Results: Three of the six probiotic species, B. lactis, L. rhamnosus, and L. acidophilus, increased in the feces of the probiotic therapy group (P<0.001), whereas there was no change in fecal microbiota in the placebo group. SIBO disappeared in many individuals of the probiotic therapy group, but none in the placebo (24 vs. 0%, P<0.05). General gastrointestinal symptoms also improved more in the probiotic group and improvement in intestinal permeability was slightly but not significantly more frequent in the probiotic arm than the placebo arm (50 vs. 31.3%, P=0.248). Numbers of lactobacilli in stool were correlated negatively with intestinal permeability (P for trend<0.05). Liver chemistry did not improve significantly in either group.

Conclusions: We conclude that short-term probiotic administration in chronic liver disease is effective in alleviating SIBO and clinical symptoms, but ineffective in improving intestinal permeability and liver function.

aDepartment of Internal Medicine, Hanyang University School of Medicine, Seoul

bCell Biotech Co., Ltd, Gimpo, Republic of Korea

Correspondence to Dae Won Jun, MD, Department of Internal Medicine, Hanyang University School of Medicine, Haengdang-dong, Sungdong-gu, Seoul 133-792, Republic of Korea Tel: +82 2 2290 8338; fax: +82 2 972 0068; e-mail:

Received June 27, 2014

Accepted August 26, 2014

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins