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Linitis-like squamous esophageal cancer diagnosed by endoscopic ultrasonography-guided fine-needle aspiration cytology: report of two cases

Adrián-de-Ganzo, Zaidaa*; Gimeno-García, Antonio Z.a*; Elwassief, Ahmedc; Paquin, Sartod; Sahai, Anand V.d; García-Castro, Candelariab; Nicolás-Pérez, Davida; Brito-García, Alejandrob; Martín-Corriente, María del Carmenb; Garièpy, Gillese; Quintero, Enriquea

European Journal of Gastroenterology & Hepatology: December 2013 - Volume 25 - Issue 12 - p 1488–1491
doi: 10.1097/MEG.0b013e3283643dfb
Case Reports

Endoscopic ultrasonography-guided fine-needle aspiration cytology (EUS-FNA) may provide full-thickness biopsies, adequate for cytology and histology. In the present case report, we describe the first cases of a rare well-differentiated squamous esophageal carcinoma (verrucous esophageal cancer), finally diagnosed by EUS-FNA using a large FNA needle after several upper endoscopies with biopsies negative for malignancy. In this report, we highlight the usefulness of this procedure and EUS features in the diagnosis of suspicious esophageal lesions with negative endoscopic biopsies for malignancy.

Departments of aGastroenterology

bPathology, Endoscopy Unit, University Hospital of Canary Islands, Tenerife, Spain

cDepartment of Internal Medicine, Gastroenterology Unit, Alhossien Hospital, Alazhar University, Cairo, Egypt

dDepartment of Gastroenterology

eDepartment of Pathology, Saint Luc University Hospital, Montreal, Quebec, Canada

*Zaida Adrián-de-Ganzo and Antonio Z. Gimeno-García contributed equally to the writing of this article.

Correspondence to Antonio Z. Gimeno-García, MD, Department of Gastroenterology, Endoscopy Unit, University Hospital of Canary Islands, Ofra s/n.38320, La Laguna, Tenerife, Spain Tel/fax: +34 922 678 554; e-mail:

Received April 22, 2013

Accepted June 13, 2013

© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins