Institutional members access full text with Ovid®

Share this article on:

Clinical significance of microRNA-93 downregulation in human colon cancer

Xiao, Zhi-Ganga,b; Deng, Zhan-Shenga; Zhang, Yang-Dea; Zhang, Yanga; Huang, Zhong-Chengb

European Journal of Gastroenterology & Hepatology: March 2013 - Volume 25 - Issue 3 - p 296–301
doi: 10.1097/MEG.0b013e32835c077a
Original Articles: Colorectal Neoplasia

Aim MicroRNA-93 (miR-93) has been shown to suppress proliferation and colony formation of colon cancer stem cells. The aim of this study was to examine the expression pattern and prognostic value of miR-93 in patients with colon cancer.

Materials and methods A quantitative real-time PCR analysis was carried out to detect the expression levels of miR-93 in 138 paired samples of tumoral and nontumoral colon tissues diagnosed with colon cancer. Associations of miR-93 expression with clinicopathological parameters and survival were also examined.

Results miR-93 expression was significantly decreased in tumoral compared with nontumoral colon tissues (P<0.001). Low miR-93 expression was significantly correlated with advanced tumor stage (P=0.02), positive nodal metastasis (P=0.006), and positive distant metastases (P=0.01). In addition, Kaplan–Meier survival analysis by Cox regression showed that low miR-93 expression [hazard ratio (HR), 10.2; 95% confidence interval (CI), 1.9–42.8, P=0.003] was associated closely with poor overall survival in patients with colon cancer. Moreover, multivariate analysis showed that miR-93 decreased expression (HR, 4.3; 95% CI, 0.8–17.2, P=0.02), advanced tumor stage (HR, 3.1; 95% CI, 0.2–13.9, P=0.04), positive nodal metastasis (HR, 4.1; 95% CI, 0.7–16.8, P=0.02), and positive distant metastases (HR, 3.7; 95% CI, 0.5–14.1, P=0.03) were independent risk factors for overall survival in patients with colon cancer.

Conclusion Our data show for the first time that the downregulation of miR-93 was significantly correlated with unfavorable clinicopathologic features and short overall survival in patients with colon cancer, suggesting that decreased expression of miR-93 be used as a novel prognostic factor for this disease.

aNational Hepatobiliary and Enteric Surgery Research Center, Ministry of Health, Central South University

bDepartment of Genenal Surgery, Hunan Provincial People’s Hospital, Hunan, People’s Republic of China

Correspondence to Yang-De Zhang, MD, National Hepatobiliary and Enteric Surgery Research Center, Ministry of Health, Central South University, Changsha, Hunan 410008, People’s Republic of China Tel/fax: +86 731 84327699; e-mail:

Received September 8, 2012

Accepted October 25, 2012

© 2013 Lippincott Williams & Wilkins, Inc.