Review ArticlesGastroesophageal reflux, dental erosion, and halitosis in epidemiological surveys a systematic reviewMarsicano, Juliane A.a; de Moura-Grec, Patrícia G.a; Bonato, Rafaela C.S.a; Sales-Peres, Matheus de Carvalhob; Sales-Peres, Arsenioa; Sales-Peres, Sílvia Helena de Carvalhoa Author Information aDepartment of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry, University of São Paulo, Bauru bDepartment of Public Health, Catanduva School of Medicine, Albino Priest Foundation, Catanduva, São Paulo, Brazil Correspondence to Sílvia Helena de Carvalho Sales-Peres, Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry, University of São Paulo, Avenue Octávio Pinheiro Brisolla, 9-75, Bauru, São 17012-901 Paulo, Brazil Tel/fax: +55 143 235 8260; e-mail: [email protected] Received July 3, 2012 Accepted September 29, 2012 European Journal of Gastroenterology & Hepatology 25(2):p 135-141, February 2013. | DOI: 10.1097/MEG.0b013e32835ae8f7 Buy Metrics Abstract In published studies, it has been suggested that dental wear is associated with gastroesophageal reflux disease (GERD). This systematic review was carried out to evaluate the association of GERD, dental erosion, and halitosis and to compare the indices adopted in epidemiological surveys. The Medline database (until October, 2011) was searched systematically to identify studies evaluating the prevalence of oral alterations, such as dental erosion and halitosis, in patients with GERD symptoms. Two reviewers analyzed all reports and the selected studies were evaluated according to the quality of evidence, using the validated Newcastle–Ottawa Quality Assessment Scale. Full-text copies of a total of 32 publications were obtained in duplicate. Sixteen publications were identified among the citations in the Bibliographic lists of studies that fulfilled the exclusion/inclusion criteria and quality of evidence. The relationship between dental erosion and GERD patients was significant in only seven studies. According to three studies, halitosis could be one of several extraesophageal symptoms or manifestations in GERD patients. In one study, it was found that the mucosa of GERD patients was significantly more acidic in comparison with that of the control group. This systematic review showed that there is a relationship between GERD and oral diseases (dental erosion and halitosis). The epidemiological surveys used different indices to analyze GERD and dental erosion. Further research could investigate the best method for assessing the two diseases. © 2013 Lippincott Williams & Wilkins, Inc.