Intake of red and processed meat confers risk of colorectal cancer (CRC). We wanted to test whether heme in meat promotes carcinogenesis.
Heme oxygenase-1 (HO-1, HMOX1) A-413T (rs2071746) was assessed in a nested case–cohort study of 383 CRC cases and 763 randomly selected participants from a prospective study of 57 053 individuals. Incidence rate ratios and 95% confidence intervals were calculated.
No association was found between the HO-1 polymorphism and CRC (P value for trend for the fully adjusted estimates=0.29). No interaction with meat intake was found (P value for interaction=0.55).
The studied HO-1 polymorphism was not associated with risk of CRC suggesting that heme from meat is not important in CRC development.
aMedical Department, Viborg Regional Hospital, Viborg
bDanish Cancer Society, Institute of Cancer Epidemiology
cNational Research Centre for the Working Environment, Copenhagen
dDepartment of Clinical Epidemiology, Aarhus University Hospital, Aalborg
eNational Food Institute, Technical University of Denmark, Soborg, Denmark
Correspondence to Vibeke Andersen, Medical Department, Viborg Regional Hospital, Heibergs Allé 4, Viborg DK-8800, Denmark Tel: +45 8927 2641; fax: +45 8927 3484; e-mail: email@example.com
Received August 5, 2010
Accepted October 12, 2010