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Heme oxygenase-1 polymorphism is not associated with riskof colorectal cancer: a Danish prospective study

Andersen, Vibekea; Christensen, Janeb; Overvad, Kimd; Tjønneland, Anneb; Vogel, Ullac,e

European Journal of Gastroenterology & Hepatology: March 2011 - Volume 23 - Issue 3 - p 282–285
doi: 10.1097/MEG.0b013e3283417f76
Original articles

Objective Intake of red and processed meat confers risk of colorectal cancer (CRC). We wanted to test whether heme in meat promotes carcinogenesis.

Methods Heme oxygenase-1 (HO-1, HMOX1) A-413T (rs2071746) was assessed in a nested case–cohort study of 383 CRC cases and 763 randomly selected participants from a prospective study of 57 053 individuals. Incidence rate ratios and 95% confidence intervals were calculated.

Results No association was found between the HO-1 polymorphism and CRC (P value for trend for the fully adjusted estimates=0.29). No interaction with meat intake was found (P value for interaction=0.55).

Conclusion The studied HO-1 polymorphism was not associated with risk of CRC suggesting that heme from meat is not important in CRC development.

aMedical Department, Viborg Regional Hospital, Viborg

bDanish Cancer Society, Institute of Cancer Epidemiology

cNational Research Centre for the Working Environment, Copenhagen

dDepartment of Clinical Epidemiology, Aarhus University Hospital, Aalborg

eNational Food Institute, Technical University of Denmark, Soborg, Denmark

Correspondence to Vibeke Andersen, Medical Department, Viborg Regional Hospital, Heibergs Allé 4, Viborg DK-8800, Denmark Tel: +45 8927 2641; fax: +45 8927 3484; e-mail:

Received August 5, 2010

Accepted October 12, 2010

© 2011 Lippincott Williams & Wilkins, Inc.