Case ReportsMcKittrick–Wheelock syndrome: a rare cause of diarrhoeaLepur, Dragana; Klinar, Igora; Miše, Brankob; Himbele, Josipa; Vranjican, Zorana; Baršić, BrunoaAuthor Information aDepartments of Neuroinfections and Intensive Care Medicine bPediatric Infectious Diseases, University Hospital for Infectious Diseases ‘Dr Fran Mihaljević’, Mirogojska 8, 10000 Zagreb, Croatia Correspondence to Dragan Lepur, MD, MSc, Department of Neuroinfections and Intensive Care Medicine, University Hospital for Infectious Diseases ‘Dr Fran Mihaljević’, Mirogojska 8, 10000 Zagreb, Croatia Tel: +385 1 4603 254; +385 1 2754 880; fax: +385 1 4603 255; e-mail: [email protected] Received 17 November 2005 Accepted 12 January 2006 European Journal of Gastroenterology & Hepatology: May 2006 - Volume 18 - Issue 5 - p 557-559 Buy Abstract McKittrick–Wheelock syndrome is a rare disorder caused by fluid and electrolyte hypersecretion from a rectal tumour. The most frequently reported tumours are villous adenomas. Dehydration with severe hyponatremia, hypokalemia, metabolic acidosis, acute renal failure and watery diarrhoea is typical. The authors present a case of McKittrick–Wheelock syndrome caused by rectal adenocarcinoma. © 2006 Lippincott Williams & Wilkins, Inc.