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Fulminant hepatitis during self-medication with hydroalcoholic extract of green tea

Gloro, Romaina; Hourmand-Ollivier, Isabellea; Mosquet, Brigitteb; Mosquet, Laurenta; Rousselot, Pierrec; Salamé, Ephremd; Piquet, Marie-Astrida; Dao, Thônga

European Journal of Gastroenterology & Hepatology: October 2005 - Volume 17 - Issue 10 - p 1135-1137
Case Reports: Liver

Despite an ancient reputation for potential phytotherapeutic effects and innocuity, traditional herbal medicine has previously been implicated in severe adverse events. Exolise is an 80% ethanolic dry extract of green tea (Camellia sinensis) standardized at 25% catechins expressed as epigallocatechin gallate, containing 5–10% caffeine. It has been available in France, Belgium, Spain and the United Kingdom since 1999, as an adjuvant therapy for use in weight loss programmes. In various studies, green tea has to date been considered useful for its potential hepatic protective properties. In this study, we report a case of fulminant hepatitis during self-medication with Exolise, requiring liver transplantation.

aService d'Hépatogastroentérologie et de Nutrition

bCentre Régional de Pharmacovigilance

cService d'Anatomopathologie

dService de Chirurgie Digestive et de transplantation Hépatique, CHU Côte de Nacre, Caen, France

Correspondence to Romain Gloro, Service d'Hépatogastroentérologie et de Nutrition, CHU Côte de Nacre, 14033 Caen, France

Tel: +33 2 31 06 45 39; e-mail:

Received 14 January 2005 Accepted 28 June 2005

© 2005 Lippincott Williams & Wilkins, Inc.