Case reportsHigh-grade dysplasia in sporadic fundic gland polyps a case report and review of the literatureJalving, Mathildea,b; Koornstra, Jan Ja,b; Götz, Jan Md; van der Waaij, Laurens Aa; de Jong, Stevenb; Zwart, Nynkeb; Karrenbeld, Arendc; Kleibeuker, Jan Ha Author Information Departments of aGastroenterology and Hepatology, bMedical Oncology and cPathology, University Hospital Groningen, Groningen, and dDepartment of Gastroenterology and Hepatology, Ny Smellinghe Hospital, Drachten, the Netherlands. Correspondence to J.H. Kleibeuker, MD, PhD, Department of Gastroenterology and Hepatology, University Hospital, PO Box 30.001, 9700 RB Groningen, the Netherlands. Tel: +31 503 613354; fax: +31 503 619306; e-mail: [email protected] Received 9 December 2002 Accepted 12 March 2003 European Journal of Gastroenterology & Hepatology 15(11):p 1229-1233, November 2003. Buy Abstract We present a case of fundic gland polyps (FGPs) containing high-grade dysplasia in a 68-year-old man. High-grade dysplasia, and even gastric adenocarcinoma, associated with FGPs have been described in patients with familial adenomatous polyposis (FAP) and attenuated familial adenomatous polyposis (AFAP) but never in non-FAP patients. Two colonoscopies in the past six years virtually rule out FAP and AFAP in our patient. Dysplasia in FGPs from non-FAP patients is extremely rare, and until now only cases of low-grade dysplasia have been described. The literature on dysplasia in FGPs is reviewed briefly. Additional immunohistochemical investigations in this case showed nuclear staining of beta-catenin, increased proliferation and apoptosis in the dysplastic areas of the FGPs. Our case suggests that the malignant potential of FGPs is not limited to FAP-associated FGPs. © 2003 Lippincott Williams & Wilkins, Inc.