Review in DepthHepatic encephalopathyOng, Janus P.a; Mullen, Kevin D.b Author Information aDepartment of Gastroenterology, Cleveland Clinic Foundation; and bMetrohealth Medical Center, Cleveland, OH, USA Correspondence to Dr Kevin D. Mullen, Department of Gastroenterology, Metrohealth Medical Center, 2500 Metrohealth Drive, Cleveland, OH 44109, USA Tel: +1 216 778 2235; fax: +1 216 778 4873; e-mail: [email protected] European Journal of Gastroenterology & Hepatology 13(4):p 325-334, April 2001. Buy Abstract In the last decade, a significant amount of research has been devoted to the pathogenesis and treatment of hepatic encephalopathy (HE). Non-invasive neuroimaging techniques such as magnetic resonance imaging and spectroscopy have become important research tools. The search for a suitable animal model of HE associated with cirrhosis is still ongoing. Moreover, consensus terminology and diagnostic criteria for HE in humans are badly needed. © 2001 Lippincott Williams & Wilkins, Inc.