We analysed different clinicopathological variables in colorectal cancer and their independent prognostic significance in order to elaborate a prognostic index, which may be used to categorize patients into homogeneous groups and indicate adjuvant therapy.
Patients (n = 108) undergoing surgery for colorectal cancer were studied (5-year-survival was controlled). Different clinicopathological variables and biological parameters (tumoural ploidy, proliferating cell nuclear antigen PCNA and nucleolar organizing regions NORs) were analysed. The Kaplan-Meier method and log-rank test were used for univariate analysis and the Cox regression method was used for multivariate analysis.
Some variables with prognostic effect in univariate analysis (e.g. rectal bleeding, altered bowel habit, intestinal obstruction, type of surgery, histological type, venous and neural invasion and invasive margin) did not have independent prognostic significance after Cox analysis. Final multivariate analysis model was defined by five parameters: postoperative carcinoembryonic antigen, Astler-Colter-Turnbull staging, histological grade, lymphatic invasion and tumour ploidy. A new Progrostic index was ellaborated that provided information to group patients in three prognostic categories of diffrent risk high, medium and low.
The Programatic index allowed categorization of patients into diffrent risk groups with identical tumoural stage ami histological grade. Therefore, this index provides better progrostic information that may be helpful when selecting patients for adjustment therapy.